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Biology subjects

Yeh, P.-T.

Publications and source records attributed to Yeh, P.-T..

2 recordsLinked to original sources

OICNet: A Neural Network for Online EEG Source Separation using Independent Component Analysis

Online source separation of EEG signals plays a crucial role in understanding and interpreting brain dynamics in real-time applications such as brain-computer interfaces (BCIs). In this paper, we propose OICNet, a novel neural network designed specifically for online EEG source separation using independent component analysis, aiming to address the challenges of real-time computational efficiency and reliable extraction of independent components from EEG data streams. The OICNet is trained on a loss function that integrates non-Gaussianity measurement and an orthogonality constraint to achieve effective decomposition of multi-channel EEG signals. We conducted comprehensive evaluation of OICNet on both task-related and task-free EEG datasets with comparison against conventional and network-based ICA counterparts. The results demonstrate that OICNet outperforms existing methods in terms of accuracy and computational efficiency. Overall, OICNet provides high-efficiency real-time EEG source separation capabilities and paves the way for advancements in deep-learning EEG processing in real-world BCI applications.

bioinformatics↗

Dual GRIN lens two-photon endoscopy for high-speed volumetric and deep brain imaging

Studying neural connections and activities in vivo is fundamental to understanding brain functions. Given the cm-size brain and three-dimensional neural circuit dynamics, deep-tissue, high-speed volumetric imaging is highly desirable for brain study. With sub-micrometer spatial resolution, intrinsic optical sectioning, and deep-tissue penetration capability, two-photon microscopy (2PM) has found a niche in neuroscience. However, current 2PM typically relies on slow axial scan for volumetric imaging, and the maximal penetration depth is only about 1 mm. Here, we demonstrate that by integrating two gradient-index (GRIN) lenses into 2PM, both penetration depth and volume-imaging rate can be significantly improved. Specifically, an 8-mm long GRIN lens allows imaging relay through a whole mouse brain, while a tunable acoustic gradient-index (TAG) lens provides sub-second volume rate via 100 kHz [~] 1 MHz axial scan. This technique enables the study of calcium dynamics in cm-deep brain regions with sub-cellular and sub-second spatiotemporal resolution, paving the way for interrogating deep-brain functional connectome.

bioengineering↗