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Yazdani, S.

Publications and source records attributed to Yazdani, S..

2 recordsLinked to original sources

Better than maximum likelihood estimation of model-based and model-free learning style

Multiple decision making systems work together to shape the final choices in human behavior. Habitual and goal-directed systems are the two most important systems that are studied in the reinforcement learning (RL) literature by model-free and model-based learning methods. Human behavior resembles the weighted combination of these systems and such a combination is modeled by weighted summation of actions value from the model based and model free systems. Extraction of this weighted parameter, which is important for many applications and computational modeling, has been mostly based on the maximum likelihood or maximum a posteriori methods. We show these methods bring many challenges and their respective extracted values are less reliable especially in the proximity of extremes values. We propose that using a free format learning method (k-nearest neighbor) which uses more information besides the fitted values e.g. global information like stay probability instead of trial by trial information can ameliorate the estimation error. The proposed method is examined by simulation and results show the advantage of the proposed method. In addition, investigation of the human behavior data from previous researchers proved the proposed method to result in more statistically robust results in predicting other behavioral indices such as the number of gaze directions toward each target. In brief, the proposed method increases the reliability of the estimated parameters and enhances the applicability of reinforcement learning paradigms in clinical trials.

neuroscience

Polygenic Link Between Blood Lipids And Amyotrophic Lateral Sclerosis

Dyslipidemia is common among patients with amyotrophic lateral sclerosis (ALS). We aimed to test the association and causality between blood lipids and ALS, using polygenic analyses on the summary results of genome-wide association studies. Polygenic risk scores (PRS) based on low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) risk alleles were significantly associated with a higher risk of ALS. Using single nucleotide polymorphisms (SNPs) specifically associated with LDL-C and TC as the instrumental variables, statistically significant causal effects of LDL-C and TC on ALS risk were identified in Mendelian randomization analysis. No significant association was noted between PRS based on triglycerides or high-density lipoprotein cholesterol risk alleles and ALS, and the PRS based on ALS risk alleles were not associated with any studied lipids. This study supports that high levels of LDL-C and TC are risk factors for ALS, and it also suggests a causal relationship of LDL-C and TC to ALS.

genetics