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Biology subjects

Wilson, R. S.

Publications and source records attributed to Wilson, R. S..

3 recordsLinked to original sources

Acclimating to degraded environments: The social rationale for swift action on restoration

As environmental degradation progresses, economies and societies adapt to the loss of ecosystem services and public attention to degradation subsides. In systems experiencing such societal acclimation to degradation, net incentives for stakeholder mitigation peak during early degradation phases and subside over time. Using harmful algae blooms in western Lake Erie as a case study, we illustrate how declines in public attention and societal reliance on lake recreation (i.e., finding recreation alternatives) reduce the incentives for stakeholders to reduce pollution runoff (i.e., mitigation efforts throughout the watershed). We then analyze how acclimation can affect a broad array of conservation challenges by developing a general socio-ecological model of societal response to degradation. We find that delays in initiating stakeholder-driven mitigation efforts can exponentially prolong restoration projects. Furthermore, when alleviating intense degradation relies upon voluntary commitments by many individuals, windows of opportunity for mitigation can be very limited because feedback loops of societal adaptation doom late restoration efforts to failure and lock human-environment systems into degraded states. These windows of opportunity can be particularly narrow when a) stakeholder mitigation requires supportive public opinion or b) even modestly valuable alternative services are available in degraded ecosystems. In such cases, maintaining undegraded human-environment regimes may hinge on quickly initiating stakeholder mitigation movements and allocating limited government conservation funds soon after degradation begins instead of spreading mitigation efforts out over decades. Such initiatives, regardless of whether acclimation is slow or rapid in a given system, also greatly accelerate the pace of environmental restoration. Significance StatementAs societies acclimate to degraded environments, mitigation efforts that hinge on action by many stakeholders can erode. Developing a socio-ecological model of acclimation, we reveal how social and environmental processes intertwine to create alternative stable socio-ecological regimes, with either: 1) undegraded ecosystem states sustained by widespread mitigation adoption, or 2) degraded states where societies neither maintain nor continue relying on traditional, local ecosystem services. This dynamic places a premium on prompt mitigation efforts, which may face narrow opportunity windows to get started and avert degraded regimes in systems that rely on stakeholder-driven mitigation. Moreover, in any system requiring stakeholder action, societal acclimation will increase the importance of early action because decaying mitigation incentives exponentially lengthen restoration efforts.

ecology↗

Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex

BackgroundPsychostimulant use disorder is a major public health issue, and despite the scope of the problem there are currently no FDA approved treatments. There would be tremendous utility in development of a treatment that could help patients both achieve and maintain abstinence. Previous work from our group has identified granulocyte-colony stimulating factor (G-CSF) as a neuroactive cytokine that alters behavioral response to cocaine, increases synaptic dopamine release, and enhances cognitive flexibility. Here, we investigate the role of G-CSF in affecting extinction and reinstatement of cocaine-seeking and perform detailed characterization of its proteomic effects in multiple limbic substructures. MethodsSprague-Dawley rats were injected with PBS or G-CSF during (1) extinction or (2) abstinence from cocaine self-administration, and drug seeking behavior was measured. Quantitative assessment of changes in the proteomic landscape in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) were performed via data-independent acquisition (DIA) mass spectrometry analysis. ResultsAdministration of G-CSF during extinction accelerated the rate of extinction, and administration during abstinence attenuated cue-induced cocaine-seeking. Analysis of global protein expression demonstrated that G-CSF regulated proteins primarily in mPFC that are critical to glutamate signaling and synapse maintenance. ConclusionTaken together, these findings support G-CSF as a viable translational research target with the potential to reduce drug craving or seeking behaviors. Importantly, recombinant G-CSF exists as an FDA-approved medication which may facilitate rapid clinical translation. Additionally, using cutting-edge multi-region discovery proteomics analyses, these studies identify a novel mechanism underlying G-CSF effects on behavioral plasticity.

neuroscience↗

Moving in complex environments: a biomechanical analysis of locomotion on inclined and narrow substrates

Characterisation of an organisms performance in different habitats provides insight into the conditions that allow it to survive and reproduce. In recent years, Northern quolls (Dasyurus hallucatus)--a medium-sized semi-arboreal marsupial native to northern Australia--have undergone significant population declines within open forest, woodland and riparian habitats, but less so in rocky areas. To explore this decline, we quantified the biomechanical performance of wild Northern quolls over inclined narrow (13 mm pole) and inclined wide (90 mm platform) substrates. We predicted that quolls may possess biomechanical adaptations to increase stability on narrow surfaces, which are more common in rocky habitats. Our results display that quolls have some biomechanical characteristics consistent with a stability advantage on narrow surfaces. This includes the coupled use of limb pairs and high grip torques (Max = 68.9 N.m, Min = -69.9 N.m), highlighting their ability to generate corrective forces to counteract the toppling moments commonly encountered during gait on narrow surfaces. However, unlike other arboreal specialists such as primates, speed was constrained on narrow surfaces, and quolls did not adopt diagonal sequence gaits. Quolls appear to adopt similar performance characteristics to cats and dogs which may limit their ability to outperform these key predators (invasive or otherwise) in particular habitats. This overlap may contribute to the declining population of Northern quolls on mainland Australia.

zoology↗