Biology subjects

Weisz, N.

Publications and source records attributed to Weisz, N..

At least 37 records · Page 2Linked to original sources

bioRxiv2022

Age-related changes in 'cortical' 1/f dynamics are explained by cardiac activity

The power of electrophysiologically measured cortical activity decays with an approximately 1/fX function. The slope of this decay (i.e. the spectral exponent, X) is modulated by various factors such as age, cognitive states or psychiatric/neurological disorders. Interestingly, a mostly parallel line of research has also uncovered similar effects for the spectral slope in the electrocardiogram (ECG). This raises the question whether these bodywide changes in spectral slopes are (in-)dependent. Focusing on well-established age-related changes in spectral slopes we analyzed a total of 1282 recordings of magnetoencephalography (MEG) resting state measurements with concurrent ECG in an age-diverse sample (18-88 years). Using a diverse array of analytical approaches, we demonstrate that the aperiodic signal recorded via surface electrodes/sensors originates from multiple physiological sources. Furthermore, our results suggest that common "artifact" rejection approaches (i.e. ICA) may not be sufficient to separate cardiac from neural activity. In particular, significant parts of age-related changes in aperiodic activity normally interpreted to be of neural origin can be explained by cardiac activity. Moreover, our results suggest that changes (flattening/steepening) of the spectral slope with age are dependent on the recording site and investigated frequency range. Our results highlight the complexity of aperiodic activity while raising concerns when interpreting aperiodic activity as "cortical" without considering physiological influences.

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bioRxiv2022

Speech intelligibility changes the temporal evolution of neural speech tracking

Listening to speech with poor signal quality is challenging. Neural speech tracking of degraded speech has been used to advance the understanding of how brain processes and speech intelligibility are interrelated, however the temporal dynamics of neural speech tracking are not clear. In the present MEG study, we thereby exploited temporal response functions (TRFs) and generated signal-degraded speech to depict the temporal evolution of speech intelligibility modulation on neural speech tracking. In addition, we inter-related facets of neural speech tracking (e.g., speech envelope reconstruction, speech-brain coherence, and components of broadband coherence spectra) to endorse our findings in TRFs. Our TRF analysis yielded marked temporally differential effects of vocoding: reduction of intelligibility went along with large increases of early peak responses ([~]50-110 ms, M50TRF), but strongly reduced responses around 175-230 ms (M200TRF). For the late responses 315-380 ms (M350TRF), the maximum response occurred for degraded speech that was still comprehensible then declined with reduced intelligibility. Furthermore, we related the TRF components to our other neural "tracking" measures and found that M50TRF and M200TRF play a differential role in the shifting center frequency of the broadband coherence spectra. Overall, our study highlights the importance of time-resolved computation and parametrization of coherence spectra on neural speech tracking and provides a better understanding of degraded speech processing. HighlightsO_LIWe use MEG to show that speech intelligibility differentially impacts the temporal evolution of neural speech tracking. C_LIO_LITRF responses around 200 ms show the strongest relationship with behaviour. C_LIO_LIRelating TRF effects to parameterized coherence spectra using FOOOF suggests that M50TRF and M200TRF reflect shifts in which speech features are tracked over time. C_LI

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bioRxiv2022

Individual prediction tendencies facilitate cortical speech tracking

Listening can be conceptualized as a process of active inference, in which the brain forms internal models to predict and integrate auditory information in a complex interaction of bottom-up and top-down processes. Whether inter-individual "prediction tendencies" shape listening experiences of real-world stimuli such as speech is, however, unknown. In the current study, we used a passive paradigm presenting tone sequences of varying entropy level, to independently quantify auditory prediction tendency (as the tendency to anticipate low-level acoustic features according to their contextual probability) for each individual. This measure was then used to predict the magnitude of cortical speech (envelope) tracking in a multi speaker listening task, where participants listened to audiobooks narrated by a target speaker in isolation or interfered by 1 or 2 distractors. Furthermore, rare semantic violations were introduced into the story, enabling us to also examine effects of word surprisal during continuous speech processing. Our results show that individual prediction tendency facilitates cortical speech tracking. Furthermore, we find interactions between individual prediction tendency and background noise as well as word surprisal in disparate brain regions. In sum, our findings suggest that individual prediction tendencies are generalizable across different listening situations and may serve as a valuable element to explain interindividual differences in natural listening experience.

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bioRxiv2022

Cochlear theta activity oscillates in phase opposition during interaural attention

It is widely established that sensory perception is a rhythmic process as opposed to a continuous one. In the context of auditory perception this effect is only established on a cortical and behavioral level. Yet, the unique architecture of the auditory sensory system allows its primary sensory cortex to modulate the processes of its sensory receptors at the cochlear level. Previously, we could demonstrate the existence of a genuine cochlear theta (~6 Hz) rhythm that is modulated in amplitude by intermodal selective attention. As the studys paradigm was not suited to assess attentional effects on the oscillatory phase of cochlear activity the question whether attention can also affect the temporal organization of the cochleas ongoing activity remained open. The present study utilizes an interaural attention paradigm to investigate ongoing otoacoustic activity during a stimulus-free cue-target interval and an omission period of the auditory target in humans. We were able to replicate the existence of the cochlear theta rhythm. Importantly, we found significant phase opposition between the two ears and attention conditions of anticipatory as well as cochlear oscillatory activity during target presentation. Yet, the amplitude was unaffected by interaural attention. These results are the first to demonstrate that intermodal and interaural attention deploy different aspects of excitation and inhibition at the first level of auditory processing. While intermodal attention modulates the level of cochlear activity, interaural attention modulates the timing.

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bioRxiv2021

Face masks impair reconstruction of acoustic speech features and higher-level segmentational features in the presence of a distractor speaker

Multisensory integration enables stimulus representation even when the sensory input in a single modality is weak. In the context of speech, when confronted with a degraded acoustic signal, congruent visual inputs promote comprehension. When this input is occluded speech comprehension consequently becomes more difficult. But it still remains inconclusive which levels of speech processing are affected under which circumstances by occlusion of the mouth area. To answer this question, we conducted an audiovisual (AV) multi-speaker experiment using naturalistic speech. In half of the trials, the target speaker wore a (surgical) face mask, while we measured the brain activity of normal hearing participants via magnetoencephalography (MEG). We additionally added a distractor speaker in half of the trials in order to create an ecologic difficult listening situation. A decoding model on the clear AV speech was trained and used to reconstruct crucial speech features in each condition. We found significant main effects of face masks on the reconstruction of acoustic features, such as the speech envelope and spectral speech features (i.e. pitch and formant frequencies), while reconstruction of higher level features of speech segmentation (phoneme and word onsets) were especially impaired through masks in difficult listening situations. As we used surgical face masks in our study, which only show mild effects on speech acoustics, we interpret our findings as the result of the occluded lip movements. This idea is in line with recent research showing that visual cortical regions track spectral modulations. Our findings extend previous behavioural results, by demonstrating the complex contextual effects of occluding relevant visual information on speech processing. HighlightsO_LISurgical face masks impair neural tracking of speech features C_LIO_LITracking of acoustic features is generally impaired, while higher level segmentational features show their effects especially in challenging listening situations C_LIO_LIAn explanation is the prevention of a visuo-phonological transformation contributing to audiovisual multisensory integration C_LI

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bioRxiv2021

Efficient prestimulus network integration of FFA biases face perception during binocular rivalry

Ongoing fluctuations in neural excitability and connectivity influence whether or not a stimulus is seen. Do they also influence which stimulus is seen? We recorded magnetoencepahlography data while participants viewed face or house stimuli, either one at a time or under bi-stable conditions induced through binocular rivalry. Multivariate pattern analysis revealed common neural substrates for rivalrous vs. non-rivalrous stimuli with an additional delay of ~36ms for the bi-stable stimulus and poststimulus signals were source-localized to the fusiform face area (FFA). Prior to stimulus onset followed by a face-vs. house-report, FFA showed stronger connectivity to primary visual cortex and to the rest of the cortex in the alpha frequency range (8-13 Hz) but there were no differences in local oscillatory alpha power. The pre-stimulus connectivity metrics predicted the accuracy of post-stimulus decoding and the delay associated with rivalry disambiguation suggesting that perceptual content is shaped by ongoing neural network states.

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bioRxiv2021

Age-related decreases of cortical visuo-phonological transformation of unheard spectral fine-details

The integration of visual and auditory cues is crucial for successful processing of speech, especially under adverse conditions. Recent reports have shown that when participants watch muted videos of speakers, the phonological information about the acoustic speech envelope is tracked by the visual cortex. However, the speech signal also carries much richer acoustic details, e.g. about the fundamental frequency and the resonant frequencies, whose visuo-phonological transformation could aid speech processing. Here, we investigated the neural basis of the visuo-phonological transformation processes of these more fine-grained acoustic details and assessed how they change with ageing. We recorded whole-head magnetoencephalography (MEG) data while participants watched silent intelligible and unintelligible videos of a speaker. We found that the visual cortex is able to track the unheard intelligible modulations of resonant frequencies and the pitch linked to lip movements. Importantly, only the processing of intelligible unheard formants decreases significantly with age in the visual and also in the cingulate cortex. This is not the case for the processing of the unheard speech envelope, the fundamental frequency or the purely visual information carried by lip movements. These results show that unheard spectral fine-details (along with the unheard acoustic envelope) are transformed from a mere visual to a phonological representation. Aging affects especially the ability to derive spectral dynamics at formant frequencies. Since listening in noisy environments should capitalize on the ability to track spectral fine-details, our results provide a novel focus on compensatory processes in such challenging situations.

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bioRxiv2021

Neural speech tracking shifts from the syllabic to the modulation rate of speech as intelligibility decreases

The most prominent acoustic features in speech are intensity modulations, represented by the amplitude envelope of speech. Synchronization of neural activity with these modulations is vital for speech comprehension. As the acoustic modulation of speech is related to the production of syllables, investigations of neural speech tracking rarely distinguish between lower-level acoustic (envelope modulation) and higher-level linguistic (syllable rate) information. Here we manipulated speech intelligibility using noise-vocoded speech and investigated the spectral dynamics of neural speech processing, across two studies at cortical and subcortical levels of the auditory hierarchy, using magnetoencephalography. Overall, cortical regions mostly track the syllable rate, whereas subcortical regions track the acoustic envelope. Furthermore, with less intelligible speech, tracking of the modulation rate becomes more dominant. Our study highlights the importance of distinguishing between envelope modulation and syllable rate and provides novel possibilities to better understand differences between auditory processing and speech/language processing disorders. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=160 SRC="FIGDIR/small/437033v1_ufig1.gif" ALT="Figure 1"> View larger version (23K): org.highwire.dtl.DTLVardef@6364adorg.highwire.dtl.DTLVardef@166daaeorg.highwire.dtl.DTLVardef@19eedd2org.highwire.dtl.DTLVardef@10f7aed_HPS_FORMAT_FIGEXP M_FIG C_FIG

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bioRxiv2021

Brain areas associated with visual spatial attention display topographic organization during auditory spatial attention

The existence of a cortical "attentional filter" in the form of spatially selective modulation of alpha power (8-14 Hz) is a dominating hypothesis in electrophysiological studies. During auditory spatial attention hemipsheric lateralized posterior alpha modulations have been reported leading to the generalization of this hypothesis. Typically, this pattern is interpreted as reflecting a top-down endogenous mechanism for suppressing distracting input from unattended directions of sound origin. The present study on auditory spatial attention rejects this interpretation by demonstrating that alpha power modulation is closely linked to oculomotor action. Towards this end, we designed an auditory paradigm in which participants were required to attend to upcoming sounds from one of 24 loudspeakers arranged in a horizontal circular array around the head. Maintaining the location of an auditory cue was associated with a topographically modulated distribution of posterior alpha power resembling the findings known from visual attention. Multivariate analyses allowed the prediction of the sound location in the horizontal plane. Importantly, this prediction was also possible, when derived from signals capturing saccadic activity. Using eye tracking, two control experiments on visual (N=122) and auditory (N=10) spatial working memory confirmed that, in absence of any visual/auditory input, lateralization of alpha power is linked to lateralized gaze direction ({+/-} 3{degrees} visual angle). Attending to an auditory stimulus engages oculomotor and visual circuits in a topographic manner akin to the retinotopic organization in vision. We conclude that allocation of spatial attention is not sufficient to account for alpha lateralization without consideration of gaze control.

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bioRxiv2021

Direct cochlear recordings show human hearing nerve activity is modulated by selective attention

The architecture of the efferent auditory system enables prioritization of strongly overlapping spatiotemporal cochlear activation patterns elicited by relevant and irrelevant inputs. So far, attempts at finding such attentional modulations of cochlear activity delivered indirect insights in humans or required direct recordings in animals. The extent to which spiral ganglion cells forming the human auditory nerve are sensitive to selective attention remains largely unknown. We investigated this question by testing the effects of attending to either the auditory or visual modality in human cochlear implant (CI) users (3 female, 13 male). Auditory nerve activity was directly recorded with standard CIs during a silent (anticipatory) cue-target interval. When attending the upcoming auditory input, ongoing auditory nerve activity within the theta range (5-8 Hz) was enhanced. Crucially, using the broadband signal (4-25 Hz), a classifier was even able to decode the attended modality from single-trial data. Follow-up analysis showed that the effect was not driven by a narrow frequency in particular. Using direct cochlear recordings from deaf individuals, our findings suggest that cochlear spiral ganglion cells are sensitive to top-down attentional modulations. Given the putatively broad hair-cell degeneration of these individuals, the effects are likely mediated by alternative efferent pathways as compared to previous studies using otoacoustic emissions. Successful classification of single-trial data could additionally have a significant impact on future closed-loop CI developments that incorporate real-time optimization of CI parameters based on the current mental state of the user. Significance StatementThe efferent auditory system in principle allows top-down modulation of auditory nerve activity, however evidence for this is lacking in humans. Using cochlear recordings in participants performing an audiovisual attention task, we show that ongoing auditory nerve activity in the silent cue-target period is directly modulated by selective attention. Specifically, ongoing auditory nerve activity is enhanced within the theta range when attending upcoming auditory input. Furthermore, over a broader frequency range, the attended modality can be decoded from single-trial data. Demonstrating this direct top-down influence on auditory nerve activity substantially extends previous works that focus on outer hair cell activity. Generally, our work could promote the use of standard cochlear implant electrodes to study cognitive neuroscientific questions.

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bioRxiv2020

Increases in parieto-occipital alpha-band power reflect involuntary spatial attention due to a task-distracting deviant sound

Imagine you are focusing on the traffic on a busy street to ride your bike safely when suddenly you hear the siren of an ambulance. This unexpected sound involuntarily captures your attention and interferes with ongoing performance. We tested whether this type of distraction involves a spatial shift of attention. We measured behavioral data and magnetoencephalographic alpha power during a crossmodal paradigm that combined an exogenous cueing task and a distraction task. In each trial, a task-irrelevant sound preceded a visual target (left or right). The sound was usually the same animal sound (i.e., standard sound). Rarely, it was replaced by an unexpected environmental sound (i.e., deviant sound). Fifty percent of the deviants occurred on the same side as the target, and 50% occurred on the opposite side. Participants responded to the location of the target. As expected, responses were slower to targets that followed a deviant compared to a standard. Crucially, this distraction effect was mitigated by the spatial relationship between the targets and the deviants: responses were faster when targets followed deviants on the same versus different side, indexing a spatial shift of attention. This was further corroborated by a posterior alpha power modulation that was higher in the hemisphere ipsilateral (vs. contralateral) to the location of the attention-capturing deviant. We suggest that this alpha power lateralization reflects a spatial attention bias. Overall, our data support the contention that spatial shifts of attention contribute to deviant distraction.

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bioRxiv2019

Phantom auditory perception (tinnitus) is characterised by stronger anticipatory auditory predictions

How phantom perceptions arise and the factors that make individuals prone to such experiences are not well understood. An attractive phenomenon to study these questions is tinnitus, a very common auditory phantom perception which is not explained by hyperactivity in the auditory pathway alone. Our framework posits that a predisposition to developing (chronic) tinnitus is dependent on individual traits relating to the formation and utilization of sensory predictions. Predictions of auditory stimulus frequency (remote from tinnitus frequency) were studied using a paradigm parametrically modulating regularity (i.e. predictability) of tone sequences and applying decoding techniques on magnetoencephalographic (MEG) data. For processes likely linked to short-term memory, individuals with tinnitus showed an enhanced anticipatory prediction pattern associated with increasing sequence regularity. In contrast, individuals without tinnitus engaged the same processes following the onset of the to-be-decoded sound. We posit that this tendency to optimally anticipate static and changing auditory inputs may determine which individuals faced with persistent auditory pathway hyperactivity factor it into auditory predictions, and thus perceive it as tinnitus. While our study constitutes a first step relating vulnerability to tinnitus with predictive processing, longitudinal studies are needed to confirm the predisposition model of tinnitus development.

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bioRxiv2019

Supramodal selective attention differentially adjusts frequency and phase of entrained oscillations in primary sensory areas and the dorsal attention network

Continuously prioritizing behaviourally relevant information from the environment for improved stimulus processing is a crucial function of attention. Low-frequency phase alignment of neural activity in primary sensory areas, with respect to attended/ignored features has been suggested to support top-down prioritization. Phase adjustment in frontoparietal regions has not been widely studied, despite general implication of these in top-down selection of information. In the current MEG study, we investigated how ongoing oscillatory activity of both sensory and non-sensory brain regions are differentially impacted by attentional focus. Participants performed an established intermodal selective attention task, where low-frequency auditory (1.6 Hz) and visual (1.8 Hz) stimuli were presented simultaneously. We instructed participants to either attend to the auditory or to the visual stimuli and to detect targets while ignoring the other stimulus stream. As expected, the strongest phase adjustment was observed in primary sensory regions for auditory and for visual stimulation, independent of attentional focus. We found greater differences in phase locking between attended and ignored stimulation for the visual modality. Interestingly, auditory temporal regions show small but significant attention-dependent entrainment even for visual stimulation. Extending findings from invasive recordings in non-human primates, we demonstrate an effect of attentional focus on the phase of the entrained oscillations in auditory and visual cortex which may be driven by phase locked increases of induced power. In contrast to the effects in sensory areas, attentional focus adjusted the peak frequencies in nonsensory areas. Spatially these areas show a striking overlap with core regions of the dorsal attention network and the frontoparietal network. This suggests that these areas prioritize the attended modality by optimally exploiting the temporal structure of stimulation. Overall, our study complements and extends previous work by showing a differential effect of attentional focus on entrained oscillations in primary sensory areas and frontoparietal areas.

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bioRxiv2019

Cochlear activity in silent cue-target intervals shows a theta rhythmic pattern and is correlated to attentional alpha modulations

A long-standing debate concerns where in the processing hierarchy of the central nervous system (CNS) selective attention takes effect. In the auditory system cochlear processes can be influenced via direct and mediated (by the inferior colliculus) projections from the auditory cortex to the superior olivary complex (SOC). Studies illustrating attentional modulations of cochlear responses have so far been limited to sound-evoked responses. The aim of the present study is to investigate intermodal (audiovisual) selective attention in humans simultaneously at the cortical and cochlear level during a stimulus-free cue-target period. We found that cochlear activity in the silent cue-target periods was modulated by a theta-rhythmic pattern ([~]6 Hz). While this pattern was present independently of attentional focus, cochlear theta activity was clearly enhanced when attending to the upcoming auditory input. On a cortical level, classical posterior alpha and beta power enhancements were found during auditory selective attention. Interestingly, participants with a stronger release of inhibition in auditory brain regions show a stronger attentional modulation of cochlear theta activity. These results hint at a putative theta-rhythmic sampling of auditory input at the cochlear level. Furthermore, our results point to an interindividual variable engagement of efferent pathways in an attentional context that are linked to processes within and beyond processes in auditory cortical regions.

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bioRxiv2019

Auditory cortical generators of the Frequency Following Response are modulated by intermodal attention

The vast efferent connectivity of the auditory system suggests that subcortical (thalamic and brainstem) auditory regions should also be sensitive to top-down processes such as selective attention. In electrophysiology, the Frequency Following Response (FFR) to simple speech stimuli has been used extensively to study these subcortical areas. Despite being seemingly straight-forward in addressing the issue of attentional modulations of subcortical regions by means of the FFR, the existing results are highly inconsistent. Moreover, the notion that the FFR exclusively represents subcortical generators has been recently challenged. By applying these techniques to data recorded from 102 magnetoencephalography (MEG) magnetometers in 34 participants during a cross-modal attention task, we aimed to gain a more differentiated perspective on how the generators of the FFR are modulated by either attending to the visual or auditory input. In a first step our results confirm the strong contribution of also cortical regions to the FFR. Interestingly, of all regions exhibiting a measurable FFR response, only the right primary auditory cortex was significantly affected by intermodal attention. By showing a clear cortical contribution to the attentional FFR effect, our work significantly extends previous reports that focus on surface level recordings only. It underlines the importance of making a greater effort to disentangle the different contributing sources of the FFR and serves as a clear precaution of simplistically interpreting the FFR as brainstem response.

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bioRxiv2019

Auditory cortical alpha desynchronization prioritizes the representation of memory items during a retention period

Maintaining information in working memory normally happens in dynamic environments, with a multitude of distracting events. This is particularly evident in the auditory system, for example, when trying to memorize a telephone number during ongoing background noise. How relevant to-be-memorized information is protected against the adverse influence of a temporally predictable distractor was the main goal of the present study. For this purpose we adapted a Sternberg task variant established in the visual modality, with either a strong or a weak distracting sound presented at a fixed time during the retention period. Our behavioral analysis confirmed a small, albeit significant deterioration of memory performance in the strong distractor condition. We used a time-generalized decoding approach applied to magnetoencephalography (MEG) data to investigate the extent of memory probe-related information prior to the anticipated distractor onset and found a relative decrease for the strong distractor condition. This effect was paralleled by a pre-distractor alpha power decrease in the left superior temporal gyrus (STG), a cortical region putatively holding memory content relevant information. Based on gating frameworks of alpha oscillations, these results could be interpreted as a failed inhibition of an anticipated strong (more salient) distractor. However, in a critical analysis we found that reduced alpha power in the left STG was associated with relatively increased memory probe-related information. Our results therefore support the view of alpha power reductions in relevant sensory (here auditory) cortical areas to be a mechanism by which to-be-remembered information is prioritized during working memory retention periods.

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bioRxiv2019

Degraded auditory and visual speech affects theta synchronization and alpha power differently

Understanding degraded speech, e.g. following a hearing damage, can pose a challenge. Previous attempts to quantify speech intelligibility in neural terms have usually focused on one of two measures, namely low-frequency speech-brain synchronization or alpha power modulations. However, reports have been mixed concerning the modulation of these measures, an issue aggravated by the fact that they have normally been studied separately. Using a parametric speech degradation approach, we present MEG studies that overcome this shortcoming. In a first study, participants listened to unimodal auditory speech with three different levels of degradation (original, 7-channel and 3-channel vocoding). Intelligibility declined with declining clarity, implemented by fewer vocoding channels but was still intelligible to some extent even for the lowest clarity level used (3-channel vocoding). Low- frequency (1-7 Hz) speech tracking suggested a u-shaped relationship with strongest effects for the medium degraded speech (7-channel) in bilateral auditory and left frontal regions. To follow up on this finding, we implemented three additional vocoding levels (5-channel, 2- channel, 1-channel) in a second MEG study. Using this wider range of degradation, the speech-brain synchronization showed a similar pattern for the degradation levels used in the first study but further shows that when speech becomes unintelligible, synchronization declines again. The relationship differed for alpha power, which continued to decrease across vocoding levels reaching a floor effect for 5-channel vocoding. Predicting subjective intelligibility based on models either combining both measures or each measure alone, showed superiority of the combined model. Our findings underline that speech tracking and alpha power are modified differently by the degree of degradation of continuous speech but together contribute to the subjective understanding of speech.

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bioRxiv2019

A backward encoding approach to recover subcortical auditory activity

1.Several subcortical nuclei along the auditory pathway are involved in the processing of sounds. One of the most commonly used methods of measuring the activity of these nuclei is the auditory brainstem response (ABR). Due to its low signal-to-noise ratio, ABRs have to be derived by averaging over thousands of artificial sounds such as clicks or tone bursts. This approach cannot be easily applied to natural listening situations (e.g. speech, music), which limits auditory cognitive neuroscientific studies to investigate mostly cortical processes. We propose that by training a backward encoding model to reconstruct evoked ABRs from high-density electrophysiological data, spatial filters can be tuned to auditory brainstem activity. Since these filters can be applied (i.e. generalized) to any other data set using the same spatial coverage, this could allow for the estimation of auditory brainstem activity from any continuous sensor level data. In this study, we established a proof-of-concept by using a backward encoding model generated using a click stimulation rate of 30 Hz to predict ABR activity recorded using EEG from an independent measurement using a stimulation rate of 9 Hz. We show that individually predicted and measured ABRs are highly correlated (r [~] 0.7). Importantly these predictions are stable even when applying the trained backward encoding model to a low number of trials, mimicking a situation with an unfavorable signal-to-noise ratio. Overall, this work lays the necessary foundation to use this approach in more interesting listening situations.

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