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Biology subjects

Wang, B.-r.

Publications and source records attributed to Wang, B.-r..

2 recordsLinked to original sources

Informing agent-based models with spatial data using convolutional autoencoders

Spatial computational models such as agent-based models (ABMs) offer powerful in silico tools to study tumor dynamics, yet imaging data are still rarely used to inform these models directly. We present an ABM optimization framework that leverages convolutional encoders to compare spatial patterns between experimental imaging data and ABM-generated outputs within a shared latent space. This quantitative comparison was used to estimate ABM parameters across three datasets, ranging from synthetic data to 3D tumoroid-T cell co-culture microscopy and histopathology images from The Cancer Genome Atlas skin cutaneous melanoma samples. Estimated parameters were evaluated using data-derived features and experimental knowledge, including experimental conditions and gene expressions. Simulations using optimized parameters reproduced key spatial features of the training images, such as tumor boundary complexity and tumor-tumor neighborhood structure. Together, these results demonstrate a flexible framework for ABM parameter optimization using spatial data across modalities, enabling systematic investigation of how spatial architecture influences tumor progression and immune interactions.

systems biology↗

Active learning-guided mechanistic modeling of CXCL9 regulation in pancreatic cancer

Cold tumors like pancreatic cancer suffer from poor immune infiltration, limiting effective anti-tumor responses. The chemokine CXCL9 promotes immune cell recruitment, but the signaling mechanisms regulating its expression in tumor cells remain poorly understood and underexplored as targets for modulation. We present a framework that integrates active learning with mechanistic logic-ODE models to guide perturbation screenings and uncover regulators of CXCL9 in pancreatic cancer cells. Using perturbation-response data and curated prior knowledge, we trained interpretable models to identify signaling mechanisms that enhance CXCL9 expression and prioritize drug combinations. Active learning enabled data-efficient model refinement and guided informative experiments under resource constraints. Benchmarking on synthetic data and experimental validation confirmed the performance of different acquisition strategies and revealed cell line-specific regulatory differences. Our results provide insight into tumor cell-intrinsic control of CXCL9 and demonstrate how combining active learning with mechanistic modeling supports rational, targeted experimental design.

systems biology↗