-Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome
1. Background 1. Background 2. Methods 3. Results 4. Discussion 5. Conclusions References Individuals with Down syndrome (DS) have an increasing age-related prevalence of Alzheimers disease (AD). In DS, the triplication of amyloid precursor protein (APP) on chromosome 21 contributes to a life-long accumulation of brain amyloid (A{beta}) [1]. Dyshomeostasis of A{beta} has emerged as one of the most well-validated factors in the pathogenesis of AD [2]. By age 40 years, virtually all individuals with DS have amyloid plaques and tau tangles, hallmark pathologies that are characteristic of sporadic AD in the general population [3]. Dementia, while not inevitable in DS, increases significantly in prevalence with age to over 75% after age 65 years. [ ...