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Van Hulle, M.

Publications and source records attributed to Van Hulle, M..

2 recordsLinked to original sources

Simple Geometric Recentering Rivals Deep Sequence Models for Cross-Session EEG Motor-Imagery Decoding

A large and growing body of work applies increasingly complex deep architectures to EEG motor-imagery (MI) decoding, yet rarely tests whether that complexity is justified against a strong, simple geometric baseline under identical conditions. We report a controlled benchmark across eight public MI datasets (3-128 channels, 2-3 classes, single- and multi-session) that holds the feature representation fixed and varies only the decoder. The central method -- a compact tangent-space pipeline on the SPD manifold with unsupervised test-time recentering, here called Geometry-Aware -- is compared against three classical Riemannian baselines (TS+SVM, FgMDM, MDM) and a family of deep models built from our own prior architecture (a bidirectional Mamba mixture-of-experts, BiMamba+MoE, with two reduced ablation variants, and an SPDNet-style network), all consuming the same single-band covariance features. Across N = 88 subject-level observations cross-session and N = 120 within-session, Geometry-Aware achieves the best average rank cross-session and is statistically tied for the best within-session (second by raw rank but indistinguishable from TS+SVM under the critical-difference test). Its cross-session advantage is large and statistically decisive -- it beats every competitor after multiple-comparison correction with large effect sizes (Cohens d = 1.06-1.50; all pFDR < 1.1 x 10-12) -- yet within session its advantage over its recentering-free twin (TS+SVM) is statistically indistinguishable (d = - 0.00, p = 0.54). This cross/within double dissociation points to recentering as the operative mechanism rather than generic capacity. The deep sequence models (the Mamba variants), despite matched features and a fair, fixed training budget, underperform every classical Riemannian method in both protocols by wide margins; the SPDNet baseline fares better -- beating MDM -- but still never beats the simple tangent-space pipeline on identical features. We argue this is a positive, well-controlled result that directly answers the reviewer-style question of whether architectural complexity is warranted. We state the limitations -- fairness of the deep-model comparison, the absence of a direct mechanistic probe, and dataset scope -- and outline how each becomes a concrete next step.

neuroscience↗

Development of a General Purpose Targeted LC-MS Method for Accurate Quantification of the SARS-CoV-2 Spike Protein Expression

The COVID-19 pandemic has catalyzed interest in immuno-multiple reaction monitoring (immuno-MRM) methods, with the detection of peptides unique to the nucleocapsid protein in nasopharyngeal swabs. While current applications predominantly focus on disease biomarkers, the pandemic has unveiled new opportunities, namely for the quantification of antigen expression following mRNA vaccination. Here, we present an optimized immuno-MRM method for quantifying SARS-CoV-2 spike protein fusion peptide, SFIEDLLFNK, for several practical applications. The method is versatile, applicable to multiple biological matrices, including plasma, and can be extended to nasopharyngeal swabs. It also offers a high-precision tool for assessing protein expression following plasmid and mRNA transfection. Moreover, in parallel to enabling accurate antigen quantification, the flow-through can be used to determine the proteome profile of the infected cells, providing insights into the intracellular immune response. This dual capability supports the rapid optimization of mRNA vaccines, thereby driving advancements in vaccine development strategies.

immunology↗