Biology subjects

Une, Y.

Publications and source records attributed to Une, Y..

4 recordsLinked to original sources

bioRxiv2026

Dermatomycosis associated with Nannizziopsis arthrosporioides in a breeding colony of gecko (Correlophus ciliatus and Rhacodactylus auriculatus).

This report describes lethal Nannizziopsis-associated dermatomycosis in a breeding colony of the family Diplodactylidae (Correlophus ciliatus and Rhacodactylus auriculatus). After introducing one gecko from overseas, three with indirect contact history died due to severe skin lesions. Extensive lesions were observed on the toe pads and ventral surface, along with necrotic dermatitis and cellulitis associated with fungi forming hyphae. Subsequently, four geckos developed diarrhea, melena, emaciation, and fungal dermatitis of the toe pads and died. Histopathologically, the fungal morphologies observed in the skin lesions of the seven geckos were consistent, and Nannizziopsis arthrosporioides was isolated and identified in two of them. To our knowledge, this is the first report of a fatal outbreak of N. arthrosporioides in geckos.

pathology↗

bioRxiv2025

First evidence of Clavicipitaceous fungus attacking a vertebrate

Metapochonia bulbillosa (Clavicipitaceae) was isolated as a causative agent of a new frog mycosis of Pelophylax porosus brevipodus, one of the endangered frogs in Japan. Analysis of spontaneous outbreaks and infection experiments confirmed that the fungus can lethally affect Pelophylax porosus brevipodus, as well as Dryophytes japonicus. This is the first evidence that a species of Clavicipitaceae, originally known as a plant pathogen, also affects vertebrates.

microbiology↗

bioRxiv2020

First report of emerging snake fungal disease caused by Ophidiomyces ophiodiicola from Asia in imported captive snakes in Japan

Snake fungal disease (SFD) (Ophidiomycosis) is an emerging infectious disease caused by the fungus Ophidiomyces ophiodiicola which has been affecting wild and captive snakes in North America, Europe, and Australia. We report the cases of 12 imported captive colubrid snakes in Japan suspected of having SFD. Pathological and microbiological examinations were performed, and the results confirmed the diagnosis of SFD in two snakes, which indicated that the remaining sympatrically raised snakes also had SFD since they exhibited similar lesions. The oral administration of ciprofloxacin in addition to itraconazole had a significant treatment effect. This is the first report of SFD in Asia caused by O. ophiodiicola. To prevent the expansion of SFD in the natural environment in Japan, there is a need to evaluate the SFD carrier status of imported snakes, the pathogenicity of the infection in native snakes, and the prevalence and distribution of SFD in wild and captive snakes. Measures also must be taken to prevent endemicity globally.

microbiology↗

bioRxiv2018

Cerebral amyloid angiopathy and comparative analysis of amyloid-β protein in birds

Senile plaques and cerebral amyloid angiopathy (CAA) are well-documented in various mammals, and several species even exhibit neurofibrillary tangle (NFT). However, we know far less about whether such symptoms are present in birds. Therefore, here we clarified the occurrence and pathogenesis of avian a{beta}-related lesions, analyzing the a{beta} amino-acid sequence across 28 birds at multiple life stages, representing 15 species, 14 genera, and 9 nine families. We also determined the expected a{beta} amino-acid sequence after comparing data from the brains of nine birds (seven species) with publicly available NCBI data. We observed CAA and senile plaque-like deposition only in a female Amazon parrot, estimated to be around 30-40 years old. We identified two A{beta} depositions (40 and 42) in the same location that correspond to A{beta} 6-42. Additionally, we observed severe A{beta} deposition, accompanied by severe hemorrhaging, in blood vessels of the superficial and deep portions of the brain. These lesions were directly related to the cause of death. Of 40 bird species, 36 exhibited type 1 A{beta} amino-acid sequences, similar to humans. Given that all of these birds were old, our results suggest that A{beta} is deposited primarily as CAA as the animals age. This report is the first clinically based description of CAA in birds. Interspecific variation likely exists because we identified species that did not exhibit A{beta} deposition even when the birds are old enough. However, even birds of the same taxonomic status differed in whether they possessed or lacked A{beta} deposition. Thus, other factors besides A{beta} amino-acid sequence could influence this symptom.

pathology↗