Biology subjects

Tseng, C.-L.

Publications and source records attributed to Tseng, C.-L..

3 recordsLinked to original sources

bioRxiv2025

YOTO (You Only Think Once): A Human EEG Dataset for Multisensory Perception and Mental Imagery

The YOTO (You Only Think Once) dataset presents a human electroencephalography (EEG) resource for exploring multisensory perception and mental imagery. The study enrolled 26 participants who performed tasks involving both unimodal and multimodal stimuli. Researchers collected high-resolution EEG signals at a 1000 Hz sampling rate to capture high-temporal-resolution neural activity related to internal mental representations. The protocol incorporated visual, auditory, and combined cues to investigate the integration of multiple sensory modalities, and participants provided self-reported vividness ratings that indicate subjective perceptual strength. Technical validation involved event-related potentials (ERPs) and power spectral density (PSD) analyses, which demonstrated the reliability of the data and confirmed distinct neural responses across stimuli. This dataset aims to foster studies on neural decoding, perception, and cognitive modeling, and it is publicly accessible for researchers who seek to advance multimodal mental imagery research and related applications.

neuroscience↗

bioRxiv2024

Innovative platelet-derived extracellular vesicle drug delivery system for the treatment of corneal neovascularization

Platelet-derived extracellular vesicles (PEVs) have drawn attention due to their multifunctionality, ease of procurement, and abundant supply from clinical-grade platelet concentrates. PEVs can be easily endocytosed owing to their lipid bilayer membrane and nanosized structure, thereby increasing the bioavailability and functionality of their therapeutic effects. PEVs also possess multiple trophic factors that make them effective therapeutic agents. Since nanomedicine offers advantages over traditional therapies for eye diseases by overcoming physical ocular barriers, PEVs combined with an anti-angiogenic agent, kaempferol (KM), were evaluated for their ability to inhibit abnormal vessel formation in the cornea. Characterization of the nanoparticles indicated successful preparation of KM- loaded PEVs (PEV-KM) with a mean diameter of [~]160 nm and an encapsulation efficiency of [~]61%. PEV-KM was efficiently internalized into human vascular endothelial cells, resulting in inhibited function, evidenced by lower wound closure rates, reduced tube formation capacity, and downregulation of angiogenesis-related gene expression. Moreover, prolonged ocular retention was observed followed by topical application of PEV and PEV-KM in mouse eyes. In an alkali-burned corneal neovascularization (CoNV) mouse model, PEV (1%) was found to reduce vessel formation in the injured cornea. PEV with KM (1% PEV with KM 6 {micro}g/mL) showed an even stronger effect in suppressing CoNV and reducing the expression of proangiogenic and inflammatory cytokines. Together, our data suggests that topical administration of PEVs or in combination with KM (PEV-KM) is a promising therapeutic for managing CoNV.

bioengineering↗

bioRxiv2021

TAK1: a potential therapeutic target for retinal neovascularization

Retinal neovascularization, or pathological angiogenesis in the retina, is a leading cause of blindness in developed countries. Transforming growth factor-{beta}-activated kinase 1 (TAK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) activated by TGF-{beta}1 and other pro-inflammatory cytokines. TAK1 is also a key mediator of inflammation, innate immune responses, apoptosis and tissue homeostasis and plays an important role in physiological angiogenesis. Its role in pathological angiogenesis, particularly in retinal neovascularization, remains unclear. We investigated the regulatory role of TAK1 in pathological angiogenesis in the retina. Transcriptome analysis of human retina featuring retinal neovascularization revealed enrichment of known TAK1-mediated signaling pathways. Selective inhibition of TAK1 activation by 5Z-7-oxozeaenol attenuated aberrant retinal angiogenesis in rats following oxygen-induced retinopathy. Transcriptome profiling revealed that TAK1 activation in human microvascular endothelial cells under TNF stimulation led to increase the gene expression related to cytokines and leukocyte-endothelial interaction, mainly through nuclear factor kappa B (NF{kappa}B) signaling pathways. These results reveal that inhibition of TAK1 signaling may have therapeutic value for the treatment of pathological angiogenesis in the retina.

biochemistry↗