Protein-protein interaction network topology as a measure of bacterial plasmid-chromosome co-evolution
In this work, we investigate the evolvability of plasmids by examining the topology of plasmid-chromosome gene interactions in Escherichia coli ST131. We discover a convergence of the ratio of non-trivial loops per protein-protein interaction, which allows us to introduce a new invariant of bacterial PPINs: the indirect connectivity value.
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