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Todorov, D.

Publications and source records attributed to Todorov, D..

4 recordsLinked to original sources

Optimal Practice Schedules in a Dual-Rate Model of Motor Adaptation, and Their Recovery by Reinforcement Learning

A clinician guiding a stroke patient through a 45-minute rehabilitation session, a coach planning a training day, a teacher choosing the order of practice problems, they all face the same question: "given everything practiced so far, what should the next trial be?" The motor-learning literature offers two coarse answers, blocked and interleaved ("random") practice, with a well-known dissociation, blocked practice gives faster acquisition but worse retention, while interleaved practice gives the opposite. We argue that this dissociation is not a fixed property of practice schedules but a shadow of a richer structure. In particular, for a learner whose memory has a fast shared component and slower context-specific components, the best schedule should be a function of the learners current internal state and the time remaining before the retention probe. We make this precise in a minimal two-context fast-slow learner model whose optimal schedules can be computed exactly for short sessions and approximated by a structured beam-search upper bound for longer ones. The optimal schedule is not blocked, not interleaved, and not a single rule; it is a family of schedules determined by how much retention is weighted relative to acquisition. The family has three regimes (alternating, mixed, blocked-with-late-correction) and for long sessions, the optimal schedule has an interpretable structure -- exploit one context, repair the neglected one, then interleave to lock in retention. We then investigate whether a reinforcement-learning teacher, observing only the learners actions and errors without access to their internal memory states, can learn these optimal policies from interaction alone. Comparing these learned policies against the exact optima, we show that a model-free agent (PPO) recovers the short-horizon schedules and the long-horizon block-repair-interleave motif in the intermediate regime, but the benchmark also exposes a sharp failure in the acquisition-dominated regime, where PPO collapses to pure blocking and misses a sparse terminal correction. A warm-start diagnostic shows this failure is a genuine metastability of policy gradients rather than a tuning artifact, with blocked-plus-switch and pure-blocked acting as competing attractors that PPO cannot stabilize between. A hyperparameter sweep over observation history reveals that the agent requires very little behavioral context to plan optimally, demonstrating that partial observability is not a major barrier to finding optimal practice schedules. Finally, we discuss the implications of our framework for motor adaptation and contextual interference, offering practical insights on how instructors can design finite practice sessions to favor long-term retention.

neuroscience↗

No evidence of neural feature-specific pre-activation during the prediction of an upcoming stimulus

Our brains constantly make predictions about upcoming events based on prior knowledge of the environment. Although several neural mechanisms have been proposed to support this capacity, it is not yet clear how the brain makes such predictions. A compelling hypothesis is that the brain preactivates a sensory template of a predictable stimulus before it appears. In a recent study, Demarchi et al. had participants listen to sequences of sounds with different levels of predictability. For some sequences, participants could anticipate the next sound (in regular sequences), for others not (in random sequences). Using magnetoencephalography recordings and machine-learning methods to decode sounds from brain signals, Demarchi et al. concluded that auditory predictions pre-activate tone-specific neural templates before the sound onset. In our reanalysis of their data, we demonstrate that their results can be fully explained by a bias induced by the structure of the sequences: because the most likely stimulus also happens to be physically close to the previous one, spurious higher-than-chance decoding performance arises before the sound onset. We provide general criteria to assess whether a study is affected by this confound and requires a reexamination. We conclude that there is no evidence of anticipatory predictive perception in the Demarchi et al. dataset, and that existing evidence for feature-specific pre-activation during prediction in humans remains inconclusive.

neuroscience↗

Beyond beta: Aperiodic broadband power reflects Parkinson's disease severity - a multicenter study

Parkinsons disease is linked to increased beta oscillations in the subthalamic nucleus, which correlate with motor symptoms. However, findings across studies have varied. Our standardized analysis of multicenter datasets shows that small sample sizes contributed to these discrepancies--a challenge we address by pooling datasets into one large cohort (n=119). Moving beyond beta power, we disentangled spectral components reflecting distinct neural processes. Combining aperiodic offset, low beta, and low gamma oscillations explained significantly more variance in symptom severity than beta alone. Moreover, interhemispheric within-patient analyses showed that, unlike beta oscillations, aperiodic broadband power-likely reflecting spiking activity-was increased in the more affected hemisphere. These findings identify aperiodic broadband power as a potential biomarker for adaptive deep brain stimulation and provide novel insights into the relationship between subthalamic hyperactivity and motor symptoms in human Parkinsons disease.

neuroscience↗

Parkinsonian rest tremor can be distinguished from voluntary hand movements based on subthalamic and cortical activity using machine learning

Tremor is one of the cardinal symptoms of Parkinsons disease. The neurophysiology of tremor is not completely understood, and so far it has not been possible to distinguish tremor from voluntary hand movements based on local brain signals. Here, we re-analyzed magnetoencephalography and local field potential recordings from the subthalamic nucleus of six patients with Parkinsons disease. Data were obtained after withdrawal from dopaminergic medication (Med Off) and after administration of levodopa (Med On). Using gradient-boosted tree learning, we classified epochs as tremor, self-paced fist-clenching, static forearm extension or tremor-free rest. While decoding performance was low when using subthalamic activity as the only feature (balanced accuracy mean: 38%, std: 7%), we could distinguish the four different motor states when considering cortical and subthalamic features (balanced accuracy mean: 75%, std: 17%). Adding a single cortical area improved classification by 17% on average, as compared to classification based on subthalamic activity alone. In most patients, the most informative cortical areas were sensorimotor cortical regions. Decoding performance was similar in Med On and Med Off. Our results demonstrate the advantage of monitoring cortical signals in addition to subthalamic activity for movement classification. By combining cortical recordings, subcortical recordings and machine learning, future adaptive systems might be able to detect tremor specifically and distinguish between several motor states.

neuroscience↗