Sunde, H. F. | Search bioRxiv

bioRxiv2024

Understanding indirect assortative mating and its intergenerational consequences

We develop a framework for understanding indirect assortative mating and provide updated definitions of key terms. We then develop family models that use partners of twins and siblings to freely estimate the degree of genetic and social homogamy, and account for it when investigating sources of parent-offspring similarity. We applied the models to educational attainment using 1,545,444 individuals in 212,070 extended families in the Norwegian population and Norwegian Twin Registry. Partner similarity in education was better explained by indirect assortment than direct assortment on observed educational attainment, with social homogamy being particularly important. The implied genotypic partner correlation (r=.34) was comparable to earlier studies, and higher than expected under direct assortment. About 38% of the parent-offspring correlation (r=.34) was attributable to various forms of environmental transmission. Alternative models that assumed direct assortment estimated environmental transmission to be lower, but these did not fit the data well.

genetics↗

bioRxiv2023

Genetic similarity between relatives provides evidence on the presence and history of assortative mating

Assortative mating - the non-random mating of individuals with similar traits - is known to increase trait-specific genetic variance and genetic similarity between relatives. However, empirical evidence is limited for many traits, and the implications hinge on whether assortative mating has started recently or many generations ago. Here we show theoretically and empirically that genetic similarity between relatives can provide evidence on the presence and history of assortative mating. First, we employed path analysis to understand how assortative mating affects genetic similarity between family members across generations, finding that similarity between distant relatives is more affected than close relatives. Next, we correlated polygenic indices of 47,135 co-parents from the Norwegian Mother, Father, and Child Cohort Study (MoBa) and found genetic evidence of assortative mating in nine out of sixteen examined traits. The same traits showed elevated similarity between relatives, especially distant relatives. Six of the nine traits, including educational attainment, showed greater genetic variance among offspring, which is inconsistent with stable assortative mating over many generations. These results suggest an ongoing increase in familial similarity for these traits. The implications of this research extend to genetic methodology and the understanding of social and economic disparities.

genetics↗