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Stippinger, M.

Publications and source records attributed to Stippinger, M..

3 recordsLinked to original sources

State-Dependent Stimulation for Seizure Termination in a Morris-Lecar Network: A Reinforcement Learning Approach

The efficacy of neurostimulation for seizure termination depends not only on the stimulus itself but also on the dynamical state of the epileptic network. Here, we develop a dynamical-systems-informed reinforcement-learning framework that learns when to deliver a predefined pulse to terminate seizure-like activity. We simulate a sparsely connected network of 100 extended three-dimensional Morris-Lecar neurons. Bifurcation analysis of the single-neuron model identifies bistable regimes and provides a mechanistic basis for considering transitions between resting and oscillatory activity. The learning agent uses semi-gradient Q-learning with tile coding and receives a two-dimensional time-delay embedding of either the population-averaged membrane potential or a derivative-based proxy for extracellular potential. It learns a state-dependent policy that selects between stimulation and no stimulation, without modifying the pulse waveform. Across 30 independently generated test networks, both learned policies markedly reduced median seizure duration compared with trigger-only and state-independent stimulation controls. The two learned policies performed comparably, indicating that the estimated extracellular potential proxy retained sufficient dynamical information for control in this model. These results provide a proof of concept that combining dynamical-systems-based state reconstruction with online reinforcement learning can identify effective stimulation timing for terminating seizure-like activity.

neuroscience↗

Low-intensity ultrasound drives offline neuromodulation through passive membrane mechanisms in synaptically isolated hippocampal neurons

Low-intensity ultrasound alters neuronal excitability long after exposure ends, but the basis of this offline effect is unclear and most proposed mechanisms require synaptic receptors. We recorded from cultured mouse hippocampal neurons in whole-cell current clamp, before and 20 min after 1 min of 850 kHz continuous-wave ultrasound at 0.5 W/cm2 or sham, with synaptic transmission blocked throughout, each neuron re-patched. Sonicated neurons remained intact and firing, yet depolarized, with smaller action potentials and more noise. A passive-membrane fit showed reduced capacitance and a depolarized leak reversal potential in every sonicated cell, with a shortened time constant and no detectable change in input conductance, while sham cells showed no significant change. Changes in the time constant and reversal potential, both independent of membrane area, indicate a modification of the membrane itself rather than a loss of area. Brief ultrasound therefore leaves a lasting, receptor-independent imprint on passive membrane properties.

neuroscience↗

Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings

State-of-the-art high-density multielectrode arrays enable the recording of simultaneous spiking activity from hundreds of neurons. Although significant efforts have been dedicated to enhancing neural recording devices and developing more efficient sorting algorithms, there has been relatively less focus on the allocation of microelectrodes--a factor that undeniably affects spike sorting effectiveness and ultimately the total number of detected neurons. Here, we systematically examined the relationship between optimal electrode spacing and spike sorting efficiency by creating virtual sparser layouts from high-density recordings through spatial downsampling. We assessed spike sorting performance by comparing the quantity of well-isolated single units per electrode in sparse configurations across various brain regions (neocortex and thalamus) and species (rat, mouse, and human). Enabling the theoretical estimation of optimal electrode arrangements, we complement experimental results with a geometrical modeling framework. Contrary to the general assumption that higher electrode density inherently leads to more efficient sorting, both our theoretical and experimental results reveal a clear optimum for electrode spacing specific to species and regions. We demonstrate that carefully choosing optimal electrode distances could yield a total of 1.7 to 3 times increase in spike sorting efficiency. These findings emphasize the necessity of species- and region-specific microelectrode design optimization.

neuroscience↗