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Biology subjects

Shu, D. Y.

Publications and source records attributed to Shu, D. Y..

2 recordsLinked to original sources

Assessing the impact of renewable energy installations on biodiversity and identifying sustainable trade-offs

Renewable energy is crucial to achieve climate neutrality, but its rapid expansion can threaten biodiversity through habitat loss or fragmentation and ecological disruption. We present a spatially explicit assessment framework that quantifies biodiversity impacts from land use change associated with renewable energy infrastructure across a broad range of species groups, and identifies siting configurations that balance energy provision and conservation goals. Drawing on metrics from life cycle assessment, combined with species distribution models and siting strategies, we evaluate alternative deployment strategies. Using Switzerland as a case study, we compare three siting strategies (maximizing energy output, minimizing biodiversity impact, and a trade-off approach) for photovoltaic systems, run-of-river hydropower, and wind turbines. For solar and hydropower installations, prioritizing energy efficiency yields the highest cumulative biodiversity losses. However, these impacts can be substantially reduced with only a slight increase in land use by favouring biodiversity protection. For wind installations, strict avoidance of sensitive ecosystems may increase total impacts, as less efficient and therefore additional sites are required to achieve the same annual energy yield. Overall, our results show that trade-off-based siting strategies can effectively balance performance and biodiversity protection, highlighting that renewable energy can be provided without sacrificing sensitive ecosystems.

ecology↗

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

Oct4, Sox2, and Klf4 (OSK) Yamanaka factors induce pluripotency and reverse age-related epigenetic changes, yet the mechanisms by which they promote rejuvenation remain poorly explored. Oxidative stress contributes to CNS aging and retinal pigmented epithelium (RPE) degeneration in age-related macular degeneration. We find that OSK expression in RPE restores retinal structure and visual function in aged mice and promotes oxidative resilience through a non-canonical, Tet2-independent pathway. Integrative functional genomics identifies GSTA4, a detoxifying enzyme that clears the lipid peroxidation byproduct 4-HNE, as a necessary and sufficient OSK effector. Dynamic GSTA4 regulation by OSK recapitulates a stem cell derived stress resilience program. GSTA4 overexpression alone enhances mitochondrial resilience, rejuvenates the aged RPE transcriptome, and reverses visual decline. GSTA4 is consistently upregulated across diverse lifespan-extending interventions suggesting a broader pro-longevity role. These findings uncover a previously unrecognized protective axis driven by Yamanaka factors that circumvents reprogramming, providing therapeutic insights for age-related diseases. HIGHLIGHTSO_LIOSK-GSTA4 provides a dynamic, Tet2-independent stress-resilience axis. C_LIO_LIFunctional genomics pinpoints GSTA4 as a direct downstream effector activated by OSK. C_LIO_LIRPE aging involves progressive accumulation of 4-HNE that can be detoxified by GSTA4. C_LIO_LIEnhancing GSTA4 rejuvenates RPE cells, restores vision and is associated with lifespan-extending interventions. C_LI

genetics↗