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Shams, R.

Publications and source records attributed to Shams, R..

4 recordsLinked to original sources

Investigating the Propagation of 0.1 - 2.5 THz Radiation Through a Phantom Ear Model: Implications for Wireless Network-Biological Tissue Interaction.

This research focuses on the investigation of the propagation of frequencies between 0.1 and 2.5 THz through a phantom ear model using terahertz (THz) time-domain spectroscopy (TDS). While the use of THz frequencies between 0.1 to 0.3 THz in fifth and sixth generation cellular networks has gained significant attention, there is also a growing interest in utilising higher frequencies, such as 1 THz and above, for various applications, including the Internet of Things (IoT), autonomous vehicles, smart sensors, and smart cities. Despite the limited absorption coefficient of soft tissues at 5G and 6G frequencies (0.2-0.4 mm), the effect of higher frequencies on deeper regions of the ear, such as the tympanic membrane (with a thickness of 0.1 mm), has not been extensively studied. The study aims to determine the optimal conditions for THz transmission through the ear canal and to investigate the interaction between wireless networks and biological tissues. The results show that when parallel to the ear canal, the average power flux density within the central region of the tympanic membrane is 97% of the incident excitation. However, the outer ear structures are highly protective, with less than 0.4% of the power flux density directed towards them reaching the same region. Due to the sensitivity of the tympanic membrane to mechanical changes, in-vivo assessments are necessary to evaluate the penetration of THz frequencies into the ear canal, assess the suitability of current radiation safety limits, and evaluate the implications of devices that emit these frequencies. The study highlights the importance of understanding the interaction between THz radiation and biological tissues, particularly in the context of emerging wireless technologies, and the need for further research to ensure their safety and effectiveness.

biophysics↗

Using Attenuated Total Reflection (ATR) to Investigate the Temperature Dependent Dielectric Properties of Tympanic Membrane, Ear Canal, and Muscle tissues.

The attenuated total reflection (ATR) setup, equipped with a diamond crystal and operating in a mixed reflection/transmission mode, demonstrated a superior and efficient capacity for investigating temperature-related interactions of biological materials at the THz-far infrared beamline at the Australian Synchrotron. This methodology was employed explicitly to investigate the temperature-driven variations in reflectance of biological tissues, such as the tympanic membrane, skeletal muscle, and brain samples, in addition to the interaction of water with THz radiation. Uniquely, the technique detected a characteristic crossover flare feature in the spectral scan, a trait inherent to water and water-based compounds. It also identified a quiet zone feature, a region exhibiting no temperature-dependent reflectance variation at higher frequencies. Remarkably, this approach required minimum sample preparation and was non-destructive, enabling the investigation of a range of tissue temperatures to ascertain the influence of temperature on the reflection and absorption dynamics of THz radiation.

biophysics↗

Transmission and Detection of 0.1-2.5 THz Through Porcine Tympanic Membrane

Research has shown that exposure to high power THz radiation can cause thermal damage to the ear, leading to hearing loss and damage to the tympanic membrane. However, more research is needed to fully understand the effects of low intensity THz radiation on the ear and to determine safe exposure levels. This study investigates the transmission of 0.1 to 2.5 THz electromagnetic waves through porcine tympanic membrane samples. Similar to human tympanic membrane, porcine ear drum is a thin layer of tissue that separates the external ear from the middle ear and plays a crucial role in the process of hearing. Using THz time-domain spectroscopy, transmission of THz waves through ex vivo porcine tympanic membrane samples was measured. Results indicate that transmission of THz waves through the tympanic membrane is frequency dependent, with higher transmission observed at lower frequencies (0.1 to 0.5 THz) and lower transmission observed at higher frequencies (2 to 2.5 THz). This study provides new insights into the transmission of THz waves through the tympanic membrane and has potential to examine potential bioeffects as a result of THz interaction.

biophysics↗

Evolution of miR-155 and its probable targets: MST1R, Adam10, and CD9 genes expression levels in adults and children gastritis patients with H. pylori infection

IntroductionH. pylori accounts for the main factor of gastric cancer which contributes to an immune response with the promotion of inflammation. Recently, the effect of miRNAs on the prognosis of diseases is gaining the attraction of investigators. Herein, we studied the expression levels of miR-155 and its identified targets (MST1R, Adam10, and CD9) along with miR-155 expression correlation with virulence factors of H. pylori (vacA and cag genes), H. pylori colonization, and inflammation, in patients candidates for gastric endoscopy due to gastritis. Methodsin this study total of 50 and 26 biopsy samples were taken from adults and children respectively. Biochemical and molecular identification of samples was performed using culture and PCR of ureC, 16sRNA, along with amplification of vacA and cagA genes for pathogenicity of bacteria. The qRT-PCR was carried out using STEM-LOOP RT-PCR (dye-based) for the evaluation of miR-155 expression level and Adam10, CD9, and MST1R expression levels. All Real-Time PCR reactions were carried out in triplicate and data analysis was conducted using REST. ResultsA total of 30 out of 17 biopsy samples in adults and children were positive for H. pylori in both PCR and culture, respectively. The expression level of miR-155 is closely related to the H. pylori infection and the down-regulation of CD9, and MST1R genes in H. pylori (+) samples compared to H. pylori (-) in adults biopsy (p=0.0001). Although, there wasnt any relation between cagA and vacA genes with the expression of miR-155 in evaluated biopsy samples in both adults and children.i ConclusionThis study for the first time revealed that the expression of MST1R, CD9, and adam10 genes was relatively related to the expression of miR-155, and indicated that the miR-155 overexpression promoted the poor prognosis of H. pylori infection in adults.

microbiology↗