Biology subjects

Seo, J.-E.

Publications and source records attributed to Seo, J.-E..

3 recordsLinked to original sources

bioRxiv2025

Figure--ground relationship of voices in musical structure modulates reciprocal frontotemporal connectivity

When listening to polyphonic music, we often perceive a melody as the figure against the ground of accompanying sounds. However, with repeated exposure, this figure-ground relationship may naturally shift, allowing the melody to recede into the ground. In a previous study, we found the consistent pattern of frontotemporal connectivity for the "Twinkle, Twinkle, Little Star" (TTLS) melody in the headings of two variations (II and IV) in Mozarts 12 Variations, K. 265, indicating that the TTLS melody, but not the different lower voices, was the figure. However, the frontotemporal connectivity pattern may change in the same phrases repeating in the two variations. In the current study, we examined how frontotemporal connectivity changes in the repeated phrases. In the results, the frontotemporal connectivity pattern between the two variations changed in the final phrase after repeated passages. This suggests that the shift in the figure-ground relationship persists, with the TTLS melody becoming less prominent while the lower voices become relatively more prominent. Additionally, frontotemporal connectivity was strongly correlated with temporofrontal connectivity in the opposite direction. Finally, our data indicate that TTLS melody-based and sensory-based processes in response to a switched figure-ground relationship, are incorporated into the bidirectional connections between frontotemporal and temporofrontal connectivity. Our study highlights the brains ability to reconfigure figure- ground relationships in the processing of musical voices.

neuroscience↗

bioRxiv2025

Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group--individual strategies

Temporal processing, including duration, is essential for survival and communication across species. Intellectual disability (ID), which has diverse causes, including Cereblon (CRBN), impairs duration discrimination. CRBN-related ID, link to abnormal cognitive behaviors, may disrupt both perception and behavior during duration discrimination. However, cross-species behavioral strategies, their variation with ID, and associated behavioral indices remain unclear. Here, humans and wild-type (WT) mice with typical intelligence, and CRBN knockout (KO) mice with ID, performed an auditory duration discrimination task with Long (10 s) and Short (2 s) cues. All groups distinguished stimulus durations, but latency-based strategies diverged. KO mice showed impulsivity and divergent responses at both individual and group levels, whereas WT mice and humans consistently delayed their responses by [~]2 s to the Short cue length, reflecting inhibition and convergent responses. In typical intelligence models, latencies for both stimuli clustered between 2-5 s, while in ID model depended on stimulus duration. Duration perception is a conserved cross-species capacity, while task-specific cognitive strategies are intrinsically preserved though variation emerges with ID. We suggest that latency indices dissociated inhibition from impulsivity, and convergence from divergence. We further suggest that CRBN-related ID preserves perceptual understanding but disrupts the shared behavioral language of typical intelligence.

neuroscience↗

bioRxiv2024

Frontotemporal connectivity changes reflect figure-ground reversal in multivoiced music

When listening to multivoiced music, it is possible to perceive distinct voices in differing pitch ranges independently. The melody that one focuses on becomes the figure, and other voices form the background. Shifting focus from one voice to another causes a figure-ground reversal, which may easily occur as a result of anticipation within repeated passages in a musical structure. We previously found that frontotemporal connectivity reflects changes in the melody of "Twinkle, Twinkle, Little Star" (TTLS) in Mozarts 12 Variations K. 265. We hypothesized that if frontotemporal connectivity remains unchanged in repeated passages, the melody of TTLS remains the figure; however, if connectivity changes, the melody shifts toward the background. Our findings show that frontotemporal connectivity only changed during the final, fourth repetition. This was accompanied by a bidirectional correlation in frontotemporal regions, implying both top-down and bottom-up processes. We captured a momentary figure-ground reversal in the multivoiced texture of continuously changing and developing music.

neuroscience↗