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Sanchez Cruz, A.

Publications and source records attributed to Sanchez Cruz, A..

2 recordsLinked to original sources

Historical use of coastal wetlands by small-scale fisheries in the Northern Gulf of California

Coastal wetlands are rich and productive ecosystems that historically have been used by small-scale fisheries due to their role as refuges, feeding, and nursery habitats for commercial target species. We used wetland resource users Local Ecological Knowledge to document historical patterns of commercial species abundance, areas of fishing importance, trophic level, and species richness and composition in coastal wetlands in the Northern Gulf of California, Mexico. We also reconstructed the environmental history of coastal wetlands in this region from bibliographic sources and photographic records, to document impacts that could have affected coastal fisheries. We found a consistent downward trend in target species abundance; the decrease was perceived as more pronounced by fishers that began fishing in or prior to the 1950s, pointing to shifting baselines, the failure for resource users to recognize environmental change and accept degraded states as normal. Areas of fishing importance within coastal wetlands also decreased through time. Trophic level of catch showed no distinct pattern across wetland sites or time. Perceived species richness and composition increased with wetland size. Our analysis of the small-scale use of coastal wetlands in the Northern Gulf is relevant to food security and can provide insight into how local populations adapt to depleted coastal food webs.

ecology↗

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The insulin receptor, a key controller of metabolism, also regulates neuronal survival and synaptic formation, maintenance, and activity. Indeed, deficient insulin receptor signaling has been implicated in several brain neurodegenerative pathologies. We present evidence linking impaired insulin receptor signaling with RP. We describe a selective decrease in the levels of the insulin receptor and its downstream effector phospho-S6 in retinal horizontal cell axons in the rd10 mouse model of RP, as well as aberrant synapses between rod photoreceptors and the postsynaptic terminals of horizontal and bipolar cells. A gene therapy strategy to induce sustained proinsulin production restored retinal insulin receptor signaling, by increasing S6 phosphorylation, without peripheral metabolic consequences. Moreover, proinsulin preserved photoreceptor synaptic connectivity and prolonged visual function in electroretinogram and optomotor tests. These findings support the therapeutic potential of proinsulin in RP.

neuroscience↗