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Salum, G.

Publications and source records attributed to Salum, G..

4 recordsLinked to original sources

MERIT: A No-Code Platform for Unifying High-Precision Cognitive Assessment Across Laboratory and Real-World Settings

Cognitive tasks are moving from the laboratory onto participants' own devices. Browser runtimes make that move easy. Their stimulus timing, however, can vary by tens of milliseconds across devices. We asked how much timing error cognitive and neural measures can tolerate. We injected per-trial stimulus-timing jitter into a public EEG dataset (ERP CORE, N = 40) and re-measured three event-related potential components. Under a prespecified criterion of half the between-participant SD, the N170 tolerated jitter up to 15.8 ms, limited by peak-latency bias. The slower MMN and P3 tolerated more than 20 ms. The full jitter distribution predicted the loss. Heavy-tailed jitter cost less than Gaussian jitter of the same RMS. In simulated reaction-time data, the same tail shape determined whether platform error raised or lowered the ex-Gaussian {tau}, a candidate attentional biomarker. A single RMS timing figure therefore cannot tell whether a platform is adequate for these measures. We built the Mobile Experimental Research Investigative Toolkit (MERIT) to meet these requirements without code. Researchers design tasks in a visual builder that supports reaction-time, continuous-control, drawing, and sequential task families. A Unity engine embedded natively in the Curious iOS and Android apps runs the tasks. Measured with an optical sensor, inter-stimulus-interval SD was 0.71 to 0.96 ms on three current phones and tablets. It was 3.73 ms on a 2019 budget Android phone. Every device measured at least four times below the N170 ceiling. In the laboratory, the same task definition streams event markers to Lab Streaming Layer (LSL) for synchronized EEG and physiological recording. In the field, it runs on ecological momentary assessment schedules. Native mobile players, no-code builders, and EMA platforms each exist as separate systems. MERIT combines them, so the task characterized against brain and body recordings in the laboratory is the same task participants complete at home.

neuroscience↗

Disentangling unity from diversity in developmental psychopathology

Developmental psychopathology has been a fruitful space for the investigation of the validity of multidimensionality. Nonetheless, previous studies in the field have not tested a model with a fine-grained division within the internalizing and externalizing spectra that also accounts for the contribution of a general psychopathology factor. The aim of this study is to test the validity and reliability of a theoretically-driven bifactor model with one general dimension and ten specific dimensions of psychopathology: fear, somatic complaints, distressful thoughts, low mood, low motivation/energy, inattention-hyperactivity, temper loss, aggression, noncompliance, and low concern for others. Our study evaluated 2,511 children aged 6-14 years-old from the Brazilian High-Risk Cohort for Psychiatric Disorders. There was support for the model in terms of its fit to the data, reliability, and external validity. Our findings highlight the potential of combined fine-grained approaches with models disentangling unity from diversity in developmental psychopathology.

animal behavior and cognition↗

Cellular correlates of cortical thinning throughout the lifespan

Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology technique and gene expression data from the Allen Human Brain Atlas to compare the regional profiles of longitudinal cortical thinning through life (4004 MRIs) with those of gene expression for several neuronal and non-neuronal cell types. The results were replicated in three independent longitudinal datasets. We found that inter-regional profiles of cortical thinning related to expression profiles for marker genes of CA1 pyramidal cells, astrocytes and microglia during development and in aging. During the two stages of life, the relationships went in opposite directions: greater gene expression related to less thinning in development and vice versa in aging. The association between cortical thinning and cell-specific gene expression was also present in mild cognitive impairment and Alzheimers Disease. These findings suggest a role of astrocytes and microglia in promoting and supporting neuronal growth and dendritic structures through life that affects cortical thickness during development, aging, and neurodegeneration. Overall, the findings contribute to our understanding of the neurobiology underlying variations in MRI-derived estimates of cortical thinning through life and late-life disease.

neuroscience↗

Balancing Strengths and Weaknesses in Dimensional Psychiatry

ObjectiveTo evaluate the feasibility and value of creating an extensible framework for psychiatric phenotyping that indexes both strengths and weaknesses of behavioral dimensions. The Extended Strengths and Weaknesses Assessment of Normal Behavior (E-SWAN) reconceptualizes each diagnostic criterion for selected DSM-5 disorders as a behavior, which can range from high (strengths) to low (weaknesses). Initial efforts have focused on Panic Disorder, Social Anxiety, Major Depression, and Disruptive Mood Dysregulation Disorder.\n\nMethodsData were collected from 523 participants (ages: 5-21 years old) in the Child Mind Institute Healthy Brain Network - an ongoing community-referred study. Parents completed each of the four E-SWAN scales and traditional unidirectional scales addressing the same disorders. Distributional properties, Item Response Theory Analysis (IRT) and Receiver Operating Characteristic (ROC) curves (for diagnostic prediction) were used to assess and compare the performance of E-SWAN and traditional scales.\n\nResultsIn contrast to the traditional scales, which exhibited truncated distributions, all four E-SWAN scales were found to have near-normal distributions. IRT analyses indicate the E-SWAN subscales provided reliable information about respondents throughout the population distribution; in contrast, traditional scales only provided reliable information about respondents at the high end of the distribution. Predictive value for DSM-5 diagnoses was comparable to prior scales.\n\nConclusionE-SWAN bidirectional scales can capture the full spectrum of the population distribution for DSM disorders. The additional information provided can better inform examination of inter-individual variation in population studies, as well as facilitate the identification of factors related to resiliency in clinical samples.

neuroscience↗