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Biology subjects

Salm, L.

Publications and source records attributed to Salm, L..

3 recordsLinked to original sources

Understanding pollination in urban food production: the importance of data validation and participant feedback for citizen science project design

O_LIThere is a significant knowledge gap regarding the pollination needs of urban farming, partly due to barriers for researchers in accessing these growing spaces. Involving growers in data collection offers a potential solution but presents other challenges in terms of data accuracy and participant retention. C_LIO_LIWe developed a citizen science methodology for monitoring plant-pollinator interactions in urban food systems and evaluated the accuracy of data collected by growers by comparison to data collected by a professionally trained researcher. We also collected feedback from participants at the mid- and endpoints of the project regarding their experiences of taking part. C_LIO_LIWhile there was some agreement between the datasets in terms of the crops most (raspberries and squash) and least attractive (tomatoes) to insects, relying only on the dataset collected by growers themselves (citizen scientists) would lead to an overestimation of the generality of relationships between crops and pollinating insects in urban food production. Possible reasons for discrepancies between the datasets include species misidentification and non-reporting of surveys where no insects were observed by citizen scientists. C_LIO_LICitizen scientists reported lack of time, concerns about data accuracy and too complex methods as barriers to participation. Implementation of their suggestions for improvements led to a 66% increase in participation in the following year, demonstrating the importance of maintaining a two-way dialogue between participants and project organisers. Citizen scientists also reported an increased appreciation and understanding of insect pollinations following participation, highlighting an additional benefit of involving urban growers in data collection. C_LI Social Impact StatementGrowing food in urban areas can contribute towards sustainable food production. We know little about urban crop pollination, and data collection can be challenging due to restricted access to growing spaces. We developed and tested the effectiveness of a method for urban growers themselves to collect data on insects visiting their crops. Comparing data to that collected by a professional researcher, we found similarities in terms of the most and least attractive crops to pollinators, but there were also large discrepancies in the datasets that mean there are limitations to relying on grower-collected data alone to understand urban plant-pollinator interactions.

ecology↗

Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis

Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to target inflammation. An important mediator of inflammation is extracellular adenosine triphosphate (ATP) that is secreted by inflamed host cells and tissues, and also by bacteria in a strain-specific and growth phase-dependent manner. Here, we investigated the mechanisms by which bacteria release ATP. Using genetic mutant strains of Escherichia coli (E. coli), we demonstrate that ATP release is dependent on ATP synthase within the inner bacterial membrane. In addition, impaired integrity of the outer bacterial membrane and bacterial death notably contribute to ATP release. In a mouse model of abdominal sepsis, local effects of bacterial ATP were analysed using a transformed E. coli bearing an arabinose-inducible periplasmic apyrase hydrolyzing ATP to be released. Abrogating bacterial ATP release shows that bacterial ATP suppresses local immune responses, resulting in reduced neutrophil counts and impaired survival. In addition, bacterial ATP has systemic effects via its transport in outer membrane vesicles (OMV). ATP-loaded OMV are quickly distributed throughout the body and upregulated expression of genes activating degranulation in neutrophils, potentially contributing to the exacerbation of sepsis severity. This study reveals mechanisms of bacterial ATP release and its local and systemic roles in sepsis pathogenesis.

microbiology↗

Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics

Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of memory-encoding neuronal ensembles influence a memory properties evolution over time. By leveraging a developmental approach to target distinct subpopulations of principal neurons, we show that memory encoding results in the concurrent establishment of multiple memory traces in the mouse hippocampus. Two of these traces are instantiated in subpopulations of early- and late-born neurons and follow distinct reactivation trajectories post-encoding. Notably, the divergent recruitment of these subpopulations underpins memory ensembles gradual reorganization, and modulates memory persistence and plasticity across multiple learning episodes. Thus, our findings reveal profound and intricate relationships between ensemble dynamics and memories progression over time.

neuroscience↗