Age-dependent Pavlovian biases influence motor decision-making
Healthy ageing is associated with decreased risk taking in motor1 and economic2-4 decision-making. However, it is unknown whether a single underlying mechanism explains these changes. Age-related changes in economic risk taking are explained by reduced Pavlovian biases that promote action toward reward2, 5, 6. Although Pavlovian biases also promote inaction in the face of punishment, the role such Pavlovian biases play in motor decision-making, which additionally depends on estimating the probability of successfully executing an action7-10, is unknown. To address this, we developed a novel app-based motor decision-making task to measure sensitivity to reward and punishment when subjects (n=26,532) made a go/no-go motor gamble based on the perceived ability to execut ...