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Rushton, S. P.

Publications and source records attributed to Rushton, S. P..

2 recordsLinked to original sources

Auditory-cognitive determinants of speech-in-noise perception: structural equation modelling of a large sample

Problems understanding speech-in-noise (SIN) are commonly associated with peripheral hearing loss. But pure tone audiometry (PTA) alone fails to fully explain SIN ability. This is because SIN perception is based on complex interactions between peripheral hearing, central auditory processing (CAP) and other cognitive abilities. We assessed interaction between these factors and age using a multivariate approach that allows the modelling of directional effects on theoretical constructs: structural equation modelling. We created a model to explain SIN using latent constructs for sound segregation, auditory (working) memory, and SIN perception, as well as PTA, age and measures of non-verbal reasoning. In a sample of 207 participants aged 18-81 years old, age was the biggest determinant of SIN ability, followed by auditory memory. PTA did not contribute to SIN directly, although it modified sound segregation ability, which covaried with auditory memory. A second model, using a CAP latent structure formed by measures of sound segregation, auditory memory, and temporal processing, revealed CAP to be the largest determinant of SIN ahead of age. Furthermore, we demonstrated the impact of PTA and non-verbal reasoning on SIN are mediated by their influence on CAP. Our results highlight the importance of central auditory processing in speech-in-noise perception.

neuroscience↗

Dopaminergic Changes in the Subgenual Cingulate Cortex in Dementia with Lewy Bodies Associates with Presence of Depression

In addition to the core clinical features of fluctuating cognition, visual hallucinations, and parkinsonism, individuals with dementia with Lewy bodies (DLB) frequently experience chronic and debilitating major depression. Treatment of depression in DLB is hampered by a lack of available effective therapies and standard serotonergic medication for major depressive disorder (MDD) is typically ineffective. Dysfunction of dopaminergic neurotransmission contributing to anhedonia and loss of motivation has been described in MDD. The subgenual anterior cingulate (sgACC) is important in mood regulation and in the symptomatic expression of depression, displaying structural, functional and metabolic abnormalities in MDD. To assess dopaminergic and serotonergic synaptic changes in DLB, post mortem sgACC tissue from DLB donors with and without depression was investigated using high-resolution stimulated emission depletion (STED) microscopy, as well as Western and dot blotting techniques. STED imaging demonstrated the presence of -synuclein within individual dopaminergic terminals in the sgACC, -synuclein presence showing a significant positive correlation with increased SNAP25 volumes in depressed DLB cases. A reduction in dopaminergic innervation in the sgACC was observed in DLB cases with depression, along with reduced levels of multiple dopaminergic markers and receptors. Limited alterations were observed in serotonergic markers. Our work demonstrates a role for dopaminergic neurotransmission in the aetiology of depression in DLB. Careful and selective targeting of dopaminergic systems may be a therapeutic option for treatment of depression in DLB.

neuroscience↗