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Biology subjects

Rogers, A. D.

Publications and source records attributed to Rogers, A. D..

2 recordsLinked to original sources

Habitat Protection Indexes - new monitoring measures for the conservation of coastal and marine habitats

A worldwide call to implement habitat protection aims to halt biodiversity loss. To monitor the extent of coastal and marine habitats within protected areas (PAs) in a standardized, open source, and reproducible way, we constructed the Local and the Global Habitat Protection Indexes (LHPI and GHPI, respectively). The LHPI pinpoints the jurisdictions with the greatest opportunity to expand their own PAs, while the GHPI showcases which jurisdictions contribute the most in area to the protection of these habitats globally. Jurisdictions were evaluated to understand which have the highest opportunity to contribute globally to the protection of habitats by meeting a target of 30% coverage of PAs with Areas Beyond National Jurisdiction (ABNJ) having the greatest opportunity to do so. While we focus on marine and coastal habitats, our workflow can be extended to terrestrial and freshwater habitats. These indexes are useful to monitor aspects of Sustainable Development Goal 14 and the emerging post-2020 Global Biodiversity Framework, to understand the current status of international cooperation on coastal and marine habitats conservation.

ecology↗

Regulation of neural stem cell fate by the transcriptional repressor Capicua

Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma. Despite its cancer link, little is known of Cics function in the brain. Here, we investigated the relationship between Cic expression and cell type specification in the brain. Cic is strongly expressed in astrocytic and neuronal lineage cells but is more weakly expressed in stem cells and oligodendroglial lineage cells. Using a new conditional Cic knockout mouse, we show that forebrain-specific Cic deletion increases proliferation and self-renewal of neural stem cells. Furthermore, Cic loss biases neural stem cells toward glial lineage selection, expanding the pool of oligodendrocyte precursor cells (OPCs). These proliferation and lineage selection effects in the developing brain are dependent on de-repression of Ets transcription factors. In patient-derived oligodendroglioma cells, CIC re-expression or ETV5 blockade decreases lineage bias, proliferation, self-renewal and tumorigenicity. Our results identify Cic is an important regulator of cell fate in neurodevelopment and oligodendroglioma, and suggest that its loss contributes to oligodendroglioma by promoting proliferation and an OPC-like identity via Ets overactivity.

cancer biology↗