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Biology subjects

Ribera, A. B.

Publications and source records attributed to Ribera, A. B..

2 recordsLinked to original sources

TO BE OR NOT TO BE A PI: ADVICE FOR TRAINEES IN THE BIOMEDICAL/BASIC SCIENCES

When a biomedical or basic science doctoral (PhD) student considers whether or not to become a Principal Investigator (PI), they typically base their decisions on anecdotal data from a limited number of faculty mentors. Alternatively, they may look online for guidance and be met with biased opinions rather than unbiased, comprehensive data. We sought to address this gap by anonymously surveying active faculty at the University of Colorado Anschutz Medical Campus (CU Anschutz) to gain more clarity on the daily life of a PI, the decisions they made as they navigated their career path, and which skills were valuable for securing a faculty position. We also identified important factors in choosing a postdoctoral lab. We found that the majority of PIs would recommend becoming a PI and thought positively of the career path, with most feeling content. But attitudes differed between faculty of different ranks. Further, in addition to scientific vision, hard work, and publications, luck was also deemed as an important factor in becoming and succeeding as a PI. We present our findings so that they may serve as a resource for graduate trainees who are considering a PI/academic research career path. In addition, the information may guide future training plans to optimize achievement of their dream career.

scientific communication and education↗

Characterising longitudinal dynamics of infant neurodevelopment using functional change point detection

SignificanceHabituation is an early-developing cognitive process linked to learning, typically reflected in functional near-infrared spectroscopy (fNIRS) studies as a reduction in evoked hemodynamic response amplitude. Conventional fNIRS analyses rely on linear time-invariance assumptions, potentially limiting insight into how responses evolve across repeated stimulus presentations. AimTo determine whether functional change point (FCPt) detection can characterize trial-specific changes in the infant hemodynamic response and reveal developmental differences in habituation timing. ApproachFunctional data analysis (FDA) treats entire response curves as statistical objects. Within this framework, FCPt detection identifies statistically significant structural shifts in the mean response across trials. FCPt detection with wild binary segmentation was applied to infant fNIRS data (n = 204) collected from infants living in rural Gambia at 5-, 8-, and 12-months of age during a habituation and novelty detection paradigm. ResultsSignificant changes were identified within auditory cortical regions. A high proportion of detected change points corresponded to decreases in response magnitude at 8- and 12-months. Ordinal regression revealed an age-related shift toward earlier occurrence of decreasing change points, indicating that older infants completed habituation sooner within the trial sequence. ConclusionFCPt detection provides temporal information on the infant hemodynamic response unavailable to conventional analysis. This additional information has revealed a previously overlooked developmental change in the habituation response during the first year of infancy.

neuroscience↗