Biology subjects

Redoute, J.

Publications and source records attributed to Redoute, J..

3 recordsLinked to original sources

bioRxiv2023

PREMISE: A database of 20 Macaca Fascicularis PET/MRI brain imaging available for research

Non-human primate (NHP) studies are unique in translational research, especially in neurosciences and neuroimaging approaches are a preferred method for scaling cross-species comparative neurosciences. In this regard, neuroimaging database development and sharing are encouraged to increase the number of subjects available to the community while limiting the number of animals used in research. We present here a simultaneous PET/MR dataset of 20 Macaca Fascicularis structured according to the Brain Imaging Data Structure (BIDS) standards. This database contains multiple MRI sequences (anatomical, diffusion and perfusion imaging notably), as well as PET perfusion and inflammation using respectively [15O]H2O and [11C]PK11195 radiotracers. We describe the pipeline method to assemble baseline data from various cohorts and qualitatively assessed all the data using signal-to-noise and contrast-to-noise ratios as well as the median of intensity. The database is stored and available through the PRIME-DE consortium repository.

scientific communication and education↗

bioRxiv2022

Upper limb rehabilitation after stroke: constraint versus intensive training. A longitudinal case-control study correlating motor performance with fMRI data

BackgroundThe reproducible beneficial effect of constraint-induced movement therapy (CIMT) in hemiparetic stroke patients makes it a good model to study brain plasticity during rehabilitation procedures. ObjectiveAssess the functional brain reorganization induced by each of the two components of CIMT: (i) non-affected upper-limb constraint and (ii) intensive training of the paretic arm. MethodsBrain activity of a right hemiparetic chronic stroke patient and of 10 healthy controls was recorded with a functional magnetic resonance imaging (fMRI) during a finger opposition task. For the patient, a total of 8 assessments were performed, before and after each component of CIMT. At each time point, brain activity during movement was compared with rest. Patients results were first compared to the control group and then correlated to motor performance across sessions. ResultsConstraint-therapy-related improvement was correlated with a decrease of cerebral activity in sensory-motor regions of both the affected and the non-affected hemispheres. Intensive-therapy-related improvement was correlated with the recruitment of pre-motor cortices and cerebellum in both hemispheres. ConclusionsTwo different patterns of brain activity underlie the effects of intensive training and constraint which could account for the respective effect of each component of the therapy.

neuroscience↗

bioRxiv2020

CERMEP-IDB-MRXFDG: A database of 37 normal adult human brain FDG PET, T1 and FLAIR MRI, and CT images available for research

We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent [18F]FDG PET/CT and MRI, resulting in [18F]FDG PET, T1 MPRAGE MRI, FLAIR MRI, and CT images. Two participants were excluded after visual quality control. We describe the acquisition parameters, the image processing pipeline and provide participants individual demographics (mean age 38 {+/-} 11.5 years, range 23-65, 20 women). Volumetric analysis of the 37 T1 MRIs showed results in line with the literature. A leave-one-out assessment of the 37 FDG images using Statistical Parametric Mapping (SPM) yielded a low number of false positives after exclusion of artefacts. The database is stored in three different formats, following the BIDS common specification: 1) DICOM (data not processed), 2) NIFTI (multimodal images coregistered to PET subject space), 3) NIFTI normalized (images normalized to MNI space). Bona fide researchers can request access to the database via a short form.

neuroscience↗