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Biology subjects

Qian, C. S.

Publications and source records attributed to Qian, C. S..

2 recordsLinked to original sources

Why do we need high-fidelity synthetic eye movement data and how should they look like?

Eye tracking has been a popular behavioral recording method across psychology, neuroscience, and computer science, but a need for large and diverse datasets has emerged. Synthetic eye movement data offer a promising complement, yet it remains unclear which aspects of real oculomotor behavior they must capture. This paper has three objectives: to clarify why synthetic eye movement data are needed, to outline what high-fidelity synthetic signals should look like, and to demonstrate how existing longitudinal datasets and subjective reports can guide their design and validation. We analyzed the motivation for synthetic eye movements and presented a framework of eye movement variance: ocassion-specific or state-specific variance, between-individual variance, pipeline induced variance and noise. Finally, we analyze subjective reports collected alongside the GazeBase dataset, demonstrating some ocassion-specific variance in data and setting requirements for state-free synthetic eye movement signals.

animal behavior and cognition↗

Mechanisms of gas sensing by internal sensory neurons in Drosophila larvae

Internal sensory neurons monitor the chemical and physical state of the body, providing critical information to the central nervous system for maintaining homeostasis and survival. A population of larval Drosophila sensory neurons, tracheal dendrite (td) neurons, elaborate dendrites along respiratory organs and may serve as a model for elucidating the cellular and molecular basis of chemosensation by internal neurons. We find that td neurons respond to decreases in O2 levels and increases in CO2 levels. We assessed the roles of atypical soluble guanylyl cyclases (Gycs) and a gustatory receptor (Gr) in mediating these responses. We found that Gyc88E/Gyc89Db were necessary for responses to hypoxia, and that Gr28b was necessary for responses to CO2. Targeted expression of Gr28b isoform c in td neurons rescued responses to CO2 in mutant larvae and also induced ectopic sensitivity to CO2 in the td network. Gas-sensitive td neurons were activated when larvae burrowed for a prolonged duration, demonstrating a natural-like feeding condition in which td neurons are activated. Together, our work identifies two gaseous stimuli that are detected by partially overlapping subsets of internal sensory neurons, and establishes roles for Gyc88E/Gyc89Db in the detection of hypoxia, and Gr28b in the detection of CO2.

neuroscience↗