Biology subjects

Perez, G. A.

Publications and source records attributed to Perez, G. A..

3 recordsLinked to original sources

bioRxiv2024

Effect of inactivated conditioned media from DENV-2-infected endothelial cells on epithelial cell healing: live cell imaging analysis.

Withdrawal StatementThe authors have withdrawn their manuscript because Several authors have expressed strong opposition to publishing in preprint, as they believe there are still important details, key experiments, and additional tests needed to complete the research. The authors argue that the study is not yet ready for publication as the investigation is still ongoing. Furthermore, some authors state that they did not grant their approval for preprint publication and therefore do not authorize its release at this stage. For these reasons, we kindly ask that our requests be respected. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. Thank you very much for your understanding and cooperation.

microbiology↗

bioRxiv2021

Acute silencing uncovers multiple forms of activity-dependent neuronal survival in the mature entorhinal cortex

Neurodegenerative diseases are characterized by selective vulnerability of distinct cell populations; however, the cause for this specificity remains elusive. Many circuits that degenerate in disease are shaped by neural activity during development, raising the possibility that mechanisms governing early cell loss may be misused when activity is compromised in the mature brain. Here we show that electrical activity and synaptic transmission are both required for neuronal survival in the adult entorhinal cortex, but these silencing methods trigger distinct means of degeneration in the same neuronal population. Competition between active and inactive cells drives axonal disintegration caused by synaptic inhibition, but not axon retraction due to electrical suppression. These findings suggest that activity-dependence may persist in some areas of the adult brain long after developmental critical periods have closed. We speculate that lifelong plasticity required to support memory may render entorhinal neurons vulnerable to prolonged activity changes in disease.

neuroscience↗

bioRxiv2020

Genetic diversity and population structure of ridge gourd (Luffa acutangula) accessions in a Tropical Asian collection using DArTseq based SNP markers

This study explored a germplasm consisting of 112 Luffa acutangula (ridge gourd) accessions mainly from Thailand, and some accessions from Vietnam, China, Philippines, Indonesia, USA, Bangladesh and Laos for an analysis of the population structure and underlying genetic diversity using 2,834 SNPs. STRUCTURE analysis ({Delta}K at K=6) allowed us to group the accessions into six subpopulations that corresponded well with the unrooted phylogenetic tree and principal coordinate analyses. The phylogenetic tree showed the diversity of L. acutangula in Thailand, and accessions from other countries apart from Thailand were grouped together in the same branches. In STRUCTURE, subpopulation 2 contained only accessions from Thailand while other subpopulations contained a combination of accessions from Thailand and from other countries. When plotted, the STRUCTURE bars to the area of collection, it revealed the geneflow from the surrounding places nearby as indicated by the admixed genetic in the STRUCTURE bars. AMOVA based on STRUCTURE clustering showed the variation between populations (12.83%) and confirmed the absence of population structure in subpopulations (-10.59%). There was a distinguishing characteristic fruit shape and length in each subpopulation. The ample genetic diversity found in the L. acutangula germplasm can be utilized in ridge gourd breeding programs to help meet the demands and needs of both consumers and farmers.

genomics↗