Biology subjects

Pawlowski, N.

Publications and source records attributed to Pawlowski, N..

2 recordsLinked to original sources

bioRxiv2017

CytoGAN: Generative Modeling of Cell Images

We explore the application of Generative Adversarial Networks to the domain of morphological profiling of human cultured cells imaged by fluorescence microscopy. When evaluated for their ability to group cell images responding to treatment by chemicals of known classes, we find that adversarially learned representations are superior to autoencoder-based approaches. While currently inferior to classical computer vision and transfer learning, the adversarial framework enables useful visualization of the variation of cellular images due to their generative capabilities.

bioinformatics↗

bioRxiv2016

Automating Morphological Profiling with Generic Deep Convolutional Networks

Morphological profiling aims to create signatures of genes, chemicals and diseases from microscopy images. Current approaches use classical computer vision-based segmentation and feature extraction. Deep learning models achieve state-of-the-art performance in many computer vision tasks such as classification and segmentation. We propose to transfer activation features of generic deep convolutional networks to extract features for morphological profiling. Our approach surpasses currently used methods in terms of accuracy and processing speed. Furthermore, it enables fully automated processing of microscopy images without need for single cell identification.

bioinformatics↗