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Biology subjects

Parreira, D.

Publications and source records attributed to Parreira, D..

2 recordsLinked to original sources

Suitable seasons: Global monthly habitat suitability for the arbovirus vectors Aedes aegypti and Aedes albopictus in 1975-2024

The mosquito species Aedes aegypti and Aedes albopictus are the primary vectors of the arboviruses dengue, Zika, and chikungunya. Expansion of these vectors into previously non-endemic regions due to climate and environmental changes has accelerated global burden from arboviral diseases. To combat this, predictive models accurately mapping Aedes habitats are essential for epidemiological modelling, effective vector control, and disease prevention. We introduce the Climademic Suitability Model, a machine learning model that delivers monthly global predictions of Aedes habitat suitability at 0.25{degrees} spatial resolution between 1975--2024. The model leverages integrated climate, land use, human population, and mosquito surveillance data to provide an explainable view of the factors governing habitat dynamics. SHAP-based explainability analysis identified temperature and dew point temperature as dominant features driving habitat suitability. Long-term analysis reveals a complex global redistribution of expanding and contracting vector habitats. Suitable areas for both species now encompass regions home to over 5 billion people, coinciding with the worlds most pronounced population growth and surpassing projections previously placing this threshold at 2050. The Climademic Suitability Model serves as a framework for near-real-time vector surveillance, climate scenario projection, and integration into transmission models to advance epidemic preparedness in an era of accelerating environmental change.

ecology↗

Decoding human placental cellular and molecular responses to maternal obesity and fetal growth

Maternal obesity increases risk of large-for-gestational-age (LGA) births and subsequent cardiometabolic disorders in offspring. To identify placental signatures associated with these outcomes, we performed single-nucleus RNAseq on placentas from women with obesity delivering appropriate-for-gestational-age (AGA) or LGA infants, compared to normal-weight controls. In maternal obesity, regardless of fetal growth, syncytiotrophoblasts showed upregulated hypoxia and TNF- signaling, while cytotrophoblasts exhibited downregulated receptor tyrosine kinase signaling. However, only in LGA placentas, villous non-trophoblasts displayed upregulated TNF- signaling and inflammatory responses. Notably, Hofbauer cells in LGA placentas presented transcriptional alterations in immunometabolism-related genes and functioned as main signaling senders via SPP1. Importantly, we recapitulated syncytiotrophoblast responses to maternal obesity using a novel microfluidic organoids-on-a-chip co-culture. These findings reveal distinct transcriptional responses of placental cell types to maternal obesity and fetal growth, highlighting potential intervention pathways to mitigate future disease risks.

developmental biology↗