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Panta, S.

Publications and source records attributed to Panta, S..

3 recordsLinked to original sources

Privacy-Preserving Visualization of Brain Functional Connectivity

Data visualizations are an integral part of neuroimging research, supporting activities ranging from exploratory data analysis to the interpretation and communication of findings. While essential, visualizations can also reveal private information about individual participants. In this paper, we discuss how visualizations may inadvertently lead to privacy leakage and explore methods to mitigate such risks. Our work investigates ways to securely share visualizations that faithfully preserve the patterns supporting the derived insights from data analysis, rather than deriving conclusions from the visualizations themselves. We address the problem of privacy-preserving visualization under the framework of differential privacy, focusing on commonly used visualization methods for functional network connectivity. Several perturbation-based strategies are investigated for protecting correlationrelated measures, with analyses of their privacy costs and the effects of pre- and post-processing. To achieve a better balance between privacy and visual utility, we propose workflows for connectogram and seed-based connectivity visualizations that preserve the qualitative structure of non-private results. Overall, this work illustrates how differential privacy can be effectively applied to neuroimaging visualization, highlighting its potential as a principled approach for safeguarding sensitive information.

neuroscience↗

Decentralized Mixed Effects Modeling in COINSTAC

Performing group analysis on magnetic resonance imaging (MRI) data with linear mixed-effects (LME) models is challenging due to its large dimensionality and inherent multi-level covariance structure. In addition, as large-scale collaborative projects become commonplace in neuroimaging, data must increasingly be stored and analysed at different locations. In such settings, substantial overheads occur in terms of data transfer and coordination between participating research groups. In some cases, data cannot be pooled together due to privacy or regulatory concerns. In this work, we propose a decentralized LME model to perform a large-scale analysis of data from different collaborations without sharing or pooling. This method is efficient as it overcomes the hurdles of data privacy for sharing and has lower bandwidth and memory requirements for analysis than the centralized modeling approach. We evaluate our model using features extracted from structural magnetic resonance imaging (sMRI) data. Results highlight gray matter reductions in the temporal lobe/insula and medical front regions demonstrate the correctness of decentralized LME models. Our analysis also demonstrates that decentralized LME models achieve similar performance compared to the models trained with all the data in one location. We also implement the decentralized LME approach in COINSTAC, a decentralized platform for federating neuroimaging analysis, to demonstrate its value to the neuroimaging community.

neuroscience↗

Enhancing Collaborative Neuroimaging Research: Introducing COINSTAC Vaults for Federated Analysis and Reproducibility

Collaborative neuroimaging research is often hindered by technological, policy, administrative, and methodological barriers, despite the abundance of available data. COINSTAC is a platform that successfully tackles these challenges through federated analysis, allowing researchers to analyze datasets without publicly sharing their data. This paper presents a significant enhancement to the COINSTAC platform: COINSTAC Vaults (CVs). CVs are designed to further reduce barriers by hosting standardized, persistent, and highly-available datasets, while seamlessly integrating with COINSTACs federated analysis capabilities. CVs offer a user-friendly interface for self-service analysis, streamlining collaboration and eliminating the need for manual coordination with data owners. Importantly, CVs can also be used in conjunction with open data as well, by simply creating a CV hosting the open data one would like to include in the analysis, thus filling an important gap in the data sharing ecosystem. We demonstrate the impact of CVs through several functional and structural neuroimaging studies utilizing federated analysis showcasing their potential to improve the reproducibility of research and increase sample sizes in neuroimaging studies.

neuroscience↗