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Biology subjects

Olsson, P.

Publications and source records attributed to Olsson, P..

2 recordsLinked to original sources

Global urban forest cover and nature access is insufficient for human wellbeing and worsening

Target 12 of the Global Biodiversity Framework urges governments to enhance human access to nature to improve human wellbeing. Here, we study nature access using several metrics for a globally representative sample of 140 large Functional Urban Areas, examining variation among regions and over time. We find most urbanites globally do not reach common benchmarks for urban forest cover and nature access. Globally, 3.3 billion people (76% of urbanites) live in urban areas that do not have at least 30% tree canopy cover. Moreover, 1.1 billion people (23% of urbanites) are farther than 1 km from a park as identified in Open Street Map, and 1.5 billion people (36% of all urbanites) are more than 1 km from a green patch as defined by land cover. Over time, urban nature access has declined. Between 1992 and 2020, most urban residents had an increase in the distance to green patches (63% of urbanites increased, average increase 680 m). Similarly, between 1992 and 2020, 31% of urbanites had a decrease in percent natural cover, while only 1.3% had an increase. We show that the variation among cities or regions in the amount of nature access depends on the metric used and the context. On average, mesic climates have more tree cover than do arid climates, and cities with lower GDP or higher population density tend to have lower natural share than other cities. Our results suggest that global urban nature access is insufficient for supporting human health and worsening over time.

ecology↗

Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

Fine mapping and bioinformatic analysis of the DDX6-CXCR5 genetic risk association in Sjogrens Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57494551, rs4938572, rs4936443, rs7117261. Functional interrogation of nuclear protein binding affinity, enhancer/promoter regulatory activity, and chromatin-chromatin interactions in immune, salivary gland epithelial, and kidney epithelial cells revealed cell type-specific allelic effects for all five SNPs that expanded regulation beyond effects on DDX6 and CXCR5 expression. Mapping the local chromatin regulatory network revealed several additional genes of interest, including lnc-PHLDB1-1. Collectively, functional characterization implicated the risk alleles of these SNPs as modulators of promoter and/or enhancer activities that regulate cell type-specific expression of DDX6, CXCR5, and lnc-PHLDB1-1, among others. Further, these findings emphasize the importance of exploring the functional significance of SNPs in the context of complex chromatin architecture in disease-relevant cell types and tissues.

genetics↗