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Biology subjects

Olsson, I. A. S.

Publications and source records attributed to Olsson, I. A. S..

2 recordsLinked to original sources

What's in it for the dogs? Assessing the outcomes of a prison-based dog training program from an animal behavior and welfare perspective

Prison-Based Dog Training Programs (PBDTPs) are gaining popularity across the world for their benefits to inmates in terms of mental and emotional health, and reduced recidivism. However, research on the implications for the dogs is limited. The aim of the present study was to assess the outcomes of a PBDTP from an animal behavior and welfare perspective. Shelter dogs (N=42) were transported to and from the prisons twice a week where they received training from inmates for a total duration of 12 weeks. Dogs were tested for potential improvements in socialization and handling skills and basic training skills using standard tests (Temperament Test and Basic Education Test). Dog welfare was assessed using behavioral, physiological, and cognitive measures, namely stress-related behaviors and overall behavior states during training sessions, salivary cortisol levels, and cognitive bias tests. Results showed that participating in the PBDTP improved the dogs sociability towards humans and increased playful behavior, and improved basic training skills including not jumping on people, walking on a leash without pulling, responding to commands (sit, down, and staying in place) and staying calm when separated from the handler. Furthermore, behaviors indicative of stress were generally rare during training sessions and no impact of the PBDTP was found on the levels of salivary cortisol nor on the dogs affective states (as measured with cognitive bias tests). In conclusion, the present study suggests that PBDPTs are beneficial for dogs, with animals showing no indicators of compromised welfare while displaying improved behavior skills, which will likely facilitate their future rehoming.

animal behavior and cognition↗

Trends in animal model preference for preclinical drug testing for type-2 diabetes and future directions

The importance of selecting accurate animal models of disease has become increasingly salient in recent years. This is particularly important for preclinical tests carried out to predict drug efficacy and safety for humans. We mapped past and current trends in animal model selection for type-2 Diabetes Mellitus (T2DM) antidiabetic drug research, and evaluate results in light of their implications for translational research. From data gathered from published studies on 41 orally administered antidiabetic drug classes from the MEDLINE Evaluator web service, we found animal model choice trends within - and across - drug classes to be substantially similar, with outbred rat strains being more prevalently used, since the 1990s. The observed consistency in choice of animal models in T2DM is advantageous for replicability and comparability of experiments, but prevalence of outbred strains raises a few concerns. In face of current criticism of the translational value of animal tests, predictive validity must be assessed on a case-by-case basis. We address some of the issues pertaining the most popular animal models in antidiabetic drug development and testing, including the lack of information on their predictive validity, and propose a back translation approach to estimate it retrospectively.

pharmacology and toxicology↗