Biology subjects

Nuismer, S. L.

Publications and source records attributed to Nuismer, S. L..

3 recordsLinked to original sources

bioRxiv2024

Using serosurveys to optimize surveillance for zoonotic pathogens

Zoonotic pathogens pose a significant risk to human health, with spillover into human populations contributing to chronic disease, sporadic epidemics, and occasional pandemics. Despite the widely recognized burden of zoonotic spillover, our ability to identify which animal populations serve as primary reservoirs for these pathogens remains incomplete. This challenge is compounded when prevalence reaches detectable levels only at specific times of year. In these cases, statistical models designed to predict the timing of peak prevalence could guide field sampling for active infections. Thus, we develop a general model that leverages routinely collected serosurveillance data to optimize sampling for elusive pathogens by predicting time windows of peak prevalence. Using simulated data sets, we show that our methodology reliably identifies times when pathogen prevalence is expected to peak. Then, we demonstrate an implementation of our method using publicly available data from two putative Ebolavirus reservoirs, straw-colored fruit bats (Eidolon helvum) and hammer-headed bats (Hypsignathus monstrosus). We envision our method being used to guide the planning of field sampling to maximize the probability of detecting active infections, and in cases when longitudinal data is available, our method can also yield predictions for the times of year that are most likely to produce future spillover events. The generality and simplicity of our methodology make it broadly applicable to a wide range of putative reservoir species where seasonal patterns of birth lead to predictable, but potentially short-lived, pulses of pathogen prevalence. AUTHOR SUMMARYMany deadly pathogens, such as Ebola, Rabies, Lassa, and Nipah viruses, originate in wildlife and jump to human populations. When this occurs, human health is at risk. At the extreme, this can lead to pandemics such as the West African Ebola epidemic and the COVID-19 pandemic. Despite the widely recognized risk wildlife pathogens pose to humans, identifying host species that serve as primary reservoirs for many pathogens remains challenging. A key obstacle to confirming reservoir hosts is sampling animals with active infections. Often, disease prevalence fluctuates seasonally in wildlife populations and only reaches detectable levels at certain times of year. In these cases, statistical models designed to predict the timing of peak prevalence could guide efficient field sampling for active infections. Therefore, we have developed a general model that uses serological data to predict times of year when pathogen prevalence is likely to peak. We demonstrate with simulated data that our method produces reliable predictions, and then demonstrate an application of our method on two hypothesized reservoirs for Ebola virus, straw-colored fruit bats and hammer-headed bats. Our method can be broadly applied to a range of potential reservoir species where seasonal patterns of birth can lead to predictable pulses of peak pathogen prevalence. Overall, our method can guide future sampling of reservoir populations and can also be used to make predictions for times of year for which future outbreaks in human populations are most likely to occur.

ecology↗

bioRxiv2020

Bridging the gap: Using reservoir ecology and human serosurveys to estimate Lassa virus incidence in West Africa

Forecasting the risk of pathogen spillover from reservoir populations of wild or domestic animals is essential for the effective deployment of interventions such as wildlife vaccination or culling. Due to the sporadic nature of spillover events and limited availability of data, developing and validating robust, spatially explicit, predictions is challenging. Recent efforts have begun to make progress in this direction by capitalizing on machine learning methodologies. An important weakness of existing approaches, however, is that they generally rely on combining human and reservoir infection data during the training process and thus conflate risk attributable to the prevalence of the pathogen in the reservoir population with the risk attributed to the realized rate of spillover into the human population. Because effective planning of interventions requires that these components of risk be disentangled, we developed a multi-layer machine learning framework that separates these processes. Our approach begins by training models to predict the geographic range of the primary reservoir and the subset of this range in which the pathogen occurs. The spillover risk predicted by the product of these reservoir specific models is then fit to data on realized patterns of historical spillover into the human population. The result is a geographically specific spillover risk forecast that can be easily decomposed and used to guide effective intervention. Applying our method to Lassa virus, a zoonotic pathogen that regularly spills over into the human population across West Africa, results in a model that explains a modest but statistically significant portion of geographic variation in historical patterns of spillover. When combined with a mechanistic mathematical model of infection dynamics, our spillover risk model predicts that 897,700 humans are infected by Lassa virus each year across West Africa, with Nigeria accounting for more than half of these human infections. Author SummaryThe 2019 emergence of SARS-CoV-2 is a grim reminder of the threat animal-borne pathogens pose to human health. Even prior to SARS-CoV-2, the spillover of pathogens from animal reservoirs was a persistent problem, with pathogens such as Ebola, Nipah, and Lassa regularly but unpredictably causing outbreaks. Machine-learning models that anticipate when and where pathogen transmission from animals to humans is likely to occur would help guide surveillance efforts and preemptive countermeasures like information campaigns or vaccination programs. We develop a novel machine learning framework that uses datasets describing the distribution of a virus within its host and the range of its animal host, along with data on spatial patterns of human immunity, to infer rates of animal-to-human transmission across a region. By training the model on data from the animal host alone, our framework allows rigorous validation of spillover predictions using human data. We apply our framework to Lassa fever, a viral disease of West Africa that is spread to humans by rodents, and use the predictions to update estimates of Lassa virus infections in humans. Our results suggest that Nigeria is most at risk for the emergence of Lassa virus, and should be prioritized for outbreak-surveillance.

ecology↗

bioRxiv2019

Bayesian estimation of Lassa virus epidemiological parameters: implications for spillover prevention using wildlife vaccination

Lassa virus is a significant burden on human health throughout its endemic region in West Africa, with most human infections the result of spillover from the primary rodent reservoir of the virus, the natal multimammate mouse, M. natalensis. Here we develop a Bayesian methodology for estimating epidemiological parameters of Lassa virus within its rodent reservoir and for generating probabilistic predictions for the efficacy of rodent vaccination programs. Our approach uses Approximate Bayesian Computation (ABC) to integrate mechanistic mathematical models, remotely-sensed precipitation data, and Lassa virus surveillance data from rodent populations. Using simulated data, we show that our method accurately estimates key model parameters, even when surveillance data are available from only a relatively small number of points in space and time. Applying our method to previously published data from two villages in Guinea estimates the time-averaged R0 of Lassa virus to be 1.658 and 1.453 for rodent populations in the villages of Bantou and Tanganya, respectively. Using the posterior distribution for model parameters derived from these Guinean populations, we evaluate the likely efficacy of vaccination programs relying on distribution of vaccine-laced baits. Our results demonstrate that effective and durable reductions in the risk of Lassa virus spillover into the human population will require repeated distribution of large quantities of vaccine. Author SummaryLassa virus is a chronic source of illness throughout West Africa, and is considered to be a threat for widespread emergence. Because most human infections result from contact with infected rodents, interventions that reduce the number of rodents infected with Lassa virus represent promising opportunities for reducing the public health burden of this disease. Evaluating how well alternative interventions are likely to perform is complicated by our relatively poor understanding of viral epidemiology within the reservoir population. Here we develop a novel statistical approach that couples mathematical models and viral surveillance data from rodent populations to robustly estimate key epidemiological parameters. Applying our method to existing data from Guinea yields well-resolved parameter estimates and allows us to simulate a variety of rodent vaccination programs. Together, our results demonstrate that rodent vaccination alone is unlikely to be an effective tool for reducing that public health burden of Lassa fever within West Africa.

ecology↗