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Biology subjects

Noisagul, P.

Publications and source records attributed to Noisagul, P..

2 recordsLinked to original sources

AI in Practice: A Multilingual Survey of 2025 BioHackathon Participants

This dataset arises from a multilingual survey of AI use among participants and community members in the DBCLS BioHackathon 2025 in Japan. The questionnaire, offered in English, Japanese, and Thai, asked about how often respondents use AI tools, what they use them for, obstacles they encounter, institutional support, satisfaction, and concerns. Additional items captured role, institution type, work country, and other demographics, totaling 105 responses. The dataset includes both raw anonymized responses and a cleaned, standardized English-only version suitable for quantitative analysis, along with the full questionnaire, a data dictionary for cleaned dataset, and a translation lookup table. Free-text answers were screened and redacted to remove URLs, names, and other potentially identifiable information. Together, these materials provide a community-level view of AI practice in genomics, bioinformatics, software development, and related areas, and can support work on AI adoption, policy, and methods for analyzing survey data on AI use in science.

scientific communication and education↗

Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis

YEATS2 is a ubiquitously expressed chromatin-associated factor that we recently identified as a novel regulator of dopaminergic (DAergic) synaptic integrity, though its mechanism of action remained unclear. Using Drosophila, we show that neuronal depletion of YEATS2 reshapes the brain transcriptome, marked by downregulation of metabolic genes and upregulation of G protein-coupled receptors (GPCRs). These changes coincide with elevated intracellular calcium, neurobehavioral deficits, and selective DA neuron loss. Importantly, genetic or pharmacological inhibition of the store-operated calcium entry channel Orai restored calcium homeostasis and rescued DA neuron survival. Our findings define a YEATS2-dependent epigenetic-calcium axis that governs DA neuron vulnerability.

neuroscience↗