Biology subjects

Niziolek, C. A.

Publications and source records attributed to Niziolek, C. A..

4 recordsLinked to original sources

bioRxiv2024

Audiomotor prediction errors drive speech adaptation even in the absence of overt movement

Observed outcomes of our movements sometimes differ from our expectations. These sensory prediction errors recalibrate the brains internal models for motor control, reflected in alterations to subsequent movements that counteract these errors (motor adaptation). While leading theories suggest that all forms of motor adaptation are driven by learning from sensory prediction errors, dominant models of speech adaptation argue that adaptation results from integrating time-advanced copies of corrective feedback commands into feedforward motor programs. Here, we tested these competing theories of speech adaptation by inducing planned, but not executed, speech. Human speakers were prompted to speak a word and, on a subset of trials, were rapidly cued to withhold the prompted speech. On standard trials, speakers were exposed to real-time playback of their own speech with an auditory perturbation of the first formant to induce single-trial speech adaptation. Speakers experienced a similar sensory error on movement cancellation trials, hearing a perturbation applied to a recording of their speech from a previous trial at the time they would have spoken. Speakers adapted to auditory prediction errors in both contexts, altering the spectral content of spoken vowels to counteract formant perturbations even when no actual movement coincided with the perturbed feedback. Such adaptation was not observed when participants passively listened to perturbed feedback without the intention to speak, ruling out observational learning as the cause of adaptation in movement cancellation trials. These results build upon recent findings in reaching, and suggest that prediction errors, rather than corrective motor commands, drive audiomotor adaptation in speech.

neuroscience↗

bioRxiv2024

Increased vowel contrast and intelligibility in connected speech induced by sensorimotor adaptation

Alterations to sensory feedback can drive robust adaptive changes to the production of consonants and vowels, but these changes often have no behavioral relevance or benefit to communication (e.g., making "head" more like "had"). This work aims to align the outcomes of adaptation with changes known to increase speech intelligibility - specifically, adaptations that increase the acoustic contrast between vowels in running speech. To this end, we implemented a vowel centralization feedback perturbation paradigm that pushes all vowels towards the center of vowel space, making them sound less distinct from one another. Speakers across the adult lifespan adapted to the centralization perturbation during sentence production, increasing the global acoustic contrast among vowels and the articulatory excursions for individual vowels. These changes persisted after the perturbation was removed, including after a silent delay, and showed robust transfer to words that were not present in the sentences. Control analyses demonstrated that these effects were unlikely to be due to explicit pronunciation strategies and occurred in the face of increasingly more rapid and less distinct production of familiar sentences. Finally, sentence transcription by crowd-sourced listeners showed that speakers vowel contrast predicted their baseline intelligibility and that experimentally-induced increases in contrast predicted intelligibility gains. These findings establish the validity of a sensorimotor adaptation paradigm to implicitly increase vowel contrast and intelligibility in connected speech, an outcome that has the potential to enhance rehabilitation in individuals who present with a reduced vowel space due to motor speech disorders, such as the hypokinetic dysarthria associated with Parkinsons disease. Significance statementDuring speech production, humans learn from perceived errors by adjusting their speech to compensate, a process known as sensorimotor adaptation. Here we leveraged sensorimotor adaptation to cause an increase in the distinctiveness of speech sounds. Specifically, speakers rapidly and implicitly learned vowel-specific articulation changes during sentence production, with positive effects on their intelligibility. This study is important for models of sensorimotor integration across all motor domains, as it demonstrates the simultaneous learning of multiple opposing transformations in the course of continuous movement. Our findings show that sensorimotor adaptation can be successfully applied to drive changes relevant to a vital ecological behavior: intelligible communication.

neuroscience↗

bioRxiv2023

Pars opercularis underlies efferent predictions and successful auditory feedback processing in speech: Evidence from left-hemisphere stroke

Hearing ones own speech allows for acoustic self-monitoring in real time. Left-hemisphere motor planning regions are thought to give rise to efferent predictions that can be compared to true feedback in sensory cortices, resulting in neural suppression commensurate with the degree of overlap between predicted and actual sensations. Sensory prediction errors thus serve as a possible mechanism of detection of deviant speech sounds, which can then feed back into corrective action, allowing for online control of speech acoustics. The goal of this study was to assess the integrity of this detection-correction circuit in persons with aphasia (PWA) whose left-hemisphere lesions may limit their ability to control variability in speech output. We recorded magnetoencephalography (MEG) while 15 PWA and age-matched controls spoke monosyllabic words and listened to playback of their utterances. From this, we measured speaking-induced suppression of the M100 neural response and related it to lesion profiles and speech behavior. Both speaking-induced suppression and cortical sensitivity to deviance were preserved at the group level in PWA. PWA with more spared tissue in pars opercularis had greater left-hemisphere neural suppression and greater behavioral correction of acoustically deviant pronunciations, whereas sparing of superior temporal gyrus was not related to neural suppression or acoustic behavior. In turn, PWA who made greater corrections had fewer overt speech errors in the MEG task. Thus, the motor planning regions that generate the efferent prediction are integral to performing corrections when that prediction is violated.

neuroscience↗

bioRxiv2021

A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech

Sensory errors caused by perturbations to movement-related feedback induce two types of behavioral changes that oppose the perturbation: rapid compensation within a movement, as well as longer-term adaptation of subsequent movements. Although adaptation is hypothesized to occur whenever a sensory error is perceived (including after a single exposure to altered feedback), adaptation of articulatory movements in speech has only been observed after repetitive exposure to auditory perturbations, questioning both current theories of speech sensorimotor adaptation as well as the universality of more general theories of adaptation. Thus, positive evidence for the hypothesized single-exposure or "one-shot" learning would provide critical support for current theories of speech sensorimotor learning and control and align adaptation in speech more closely with other motor domains. We measured one-shot learning in a large dataset in which participants were exposed to intermittent, unpredictable auditory perturbations to their vowel formants (the resonant frequencies of the vocal tract that distinguish between different vowels). On each trial, participants spoke a word out loud while their first formant was shifted up, shifted down, or remained unshifted. We examined whether the perturbation on a given trial affected speech on the subsequent, unperturbed trial. We found that participants adjusted their first formant in the opposite direction of the preceding shift, demonstrating that learning occurs even after a single auditory perturbation as predicted by current theories of sensorimotor adaptation. While adaptation and the preceding compensation responses were correlated, this was largely due to differences across individuals rather than within-participant variation from trial to trial. These findings are more consistent with theories that hypothesize adaptation is driven directly by updates to internal control models than those that suggest adaptation results from incorporation of feedback responses from previous productions.

neuroscience↗