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Biology subjects

Mougin, F.

Publications and source records attributed to Mougin, F..

2 recordsLinked to original sources

Knee Biomechanics during Walking in Individuals with Anterior Cruciate Ligament Repair: The Role of a Custom 3D Printed Knee Brace

BackgroundAnterior cruciate ligament (ACL) injuries frequently lead to altered gait biomechanics and muscle activation patterns, increasing the risk of osteoarthritis. Knee braces are commonly used to address these issues although a lack of consensus remains regarding their clinical benefits. The recent emergence of 3D-printed braces, lighter and personalized, could improve rehabilitation. ObjectivesTo evaluate the effect of a novel custom-made 3D-printed knee brace (Provoke) in individuals after unilateral ACL reconstruction during walking. The brace incorporates an asymmetrical hinge system aimed at stabilizing the knee joint while minimizing compensatory movements. MethodsFourteen participants with unilateral ACL reconstruction wore the Provoke brace while walking at comfortable and fast paces. Knee kinematics and kinetics, and muscular activity (rectus femoris, vastus medialis, and semitendinosus) were assessed with and without the brace. Two-tailed non-parametric paired T-tests were used to assess the biomechanical effect of the brace. Results and conclusionsThe Provoke brace improved knee kinematics, facilitating a more neutral knee position by reducing valgus angles (-1.95{degrees}), and increasing flexion angles (+1.14{degrees}). Additionally, it enhanced muscle activation, particularly of the rectus femoris, suggesting improved quadriceps function. Overall, the Provoke brace effectively improves knee function and reduces muscle imbalances in individuals undergoing ACL reconstruction. It may help prevent further injury and reduce the risk of post-traumatic osteoarthritis development. The long-term effects of brace use in ACL rehabilitation must be investigated. Key PointsO_LIWalking while wearing Provoke brace allow to reduce knee valgus angles which could counteract the development of post-traumatic osteoarthritis. C_LIO_LIBraced walking may mitigate the stiffened knee gait strategy by increasing the peak knee flexion angle during the stance phase of the gait. C_LIO_LIIncreased rectus femoris activation during early stance phase could improve knee function and stability, acting against quadriceps weakness often observed after anterior cruciate ligament reconstruction. C_LI

bioengineering↗

GSAn: an alternative to enrichment analysis for annotating gene sets

The revolution in new sequencing technologies, by strongly improving the production of omics data, is greatly leading to new understandings of the relations between genotype and phenotype. To interpret and analyze these massive data that are grouped according to a phenotype of interest, methods based on statistical enrichment became a standard in biology. However, these methods synthesize the biological information by a priori selecting the over-represented terms and may suffer from focusing on the most studied genes that represent a limited coverage of annotated genes within the gene set.\n\nTo address these limitations, we developed GSAn, a novel gene set annotation Web server that uses semantic similarity measures to reduce a priori Gene Ontology annotation terms. The originality of this new approach is to identify the best compromise between the number of retained annotation terms that has to be drastically reduced and the number of related genes that has to be as large as possible. Moreover, GSAn offers interactive visualization facilities dedicated to the multi-scale analysis of gene set annotations. GSAn is available at: https://gsan.labri.fr.

bioinformatics↗