Biology subjects

Melnick, M. D.

Publications and source records attributed to Melnick, M. D..

4 recordsLinked to original sources

bioRxiv2020

Online Transcranial Random Noise stimulation improves perception at high levels of visual white noise

Transcranial random noise stimulation (tRNS), a relatively recent addition to the field of non-invasive, electrical brain stimulation, has been shown to improve perceptual and cognitive functions across a wide variety of tasks. However, the underlying mechanisms of visual improvements caused by tRNS remain unclear. To study this question, we employed a well-established, equivalent-noise approach, which measures perceptual performance at various levels of external noise and is formalized by the Perceptual Template Model (PTM). This approach has been used extensively to infer the underlying mechanisms behind changes in visual processing, including those from perceptual training, adaptation and attention. Here, we used tRNS during an orientation discrimination task in the presence of increasing quantities of external visual white noise and fit the PTM to gain insights into the effects of tRNS on visual processing. Our results show that tRNS improves visual processing when stimulation is applied during task performance, but only at high levels of external visual white noise--a signature of improved external noise filtering. There were no significant effects of tRNS on task performance after the stimulation period. Of interest, the reported effects of tRNS on visual processing mimic those previously reported for endogenous spatial attention, offering a potential area of investigation for future work.

neuroscience↗

bioRxiv2020

Changes in perilesional V1 underlie training-induced recovery in cortically-blind patients

Damage to the primary visual cortex (V1) causes profound, homonymous visual-field loss termed cortical blindness (CB). Though long considered intractable, multiple studies now show that perceptual training can recover visual functions in chronic CB. A popular hypothesis is that training recruits intact extrageniculostriate pathways. Alternatively, training may induce plastic changes within spared regions of the damaged V1. Here, we linked changes in luminance detection sensitivity with retinotopic fMRI activity in eleven chronic CB patients, before and after extensive visual discrimination training. Our results show that the strength of spared V1 activity representing perimetrically blind-field locations before training predicts the amount of training-induced recovery of luminance detection sensitivity. Additionally, training caused an enlargement of population receptive fields in perilesional V1 cortex, which increased blind-field coverage. These findings uncover fundamental changes in perilesional V1 cortex underlying training-induced restoration of conscious luminance detection sensitivity in cortically-blind patients.

neuroscience↗

bioRxiv2019

Time is vision: functional preservation and enhanced capacity for recovery in subacute occipital stroke

Stroke damage to the primary visual cortex (V1) causes a loss of vision known as hemianopia or cortically-induced blindness (CB). While early, spontaneous, perimetric improvements can occur, by 6 months post-stroke, the deficit is considered chronic and permanent. Despite evidence from sensorimotor stroke showing that early injury responses heighten neuroplastic potential, to date, rehabilitation research has focused only on chronic CB patients. Consequently, little is known about the functional properties of subacute, post-stroke visual systems, and whether they can be harnessed to enhance visual recovery. Here, for the first time, we show that conscious visual discrimination abilities are partially preserved inside subacute, perimetrically-defined blind fields, disappearing by 6 months post-stroke. Complementing this discovery, we show that global motion discrimination training initiated subacutely leads to comparable magnitude of recovery as that initiated in chronic CB. However, it does so 6 times faster, generalizes to deeper, untrained regions of the blind field, and to other [untrained] aspects of motion perception, preventing their degradation upon reaching the chronic period. Untrained subacutes exhibited only spontaneous improvements in perimetry - spontaneous recovery of motion discriminations was never observed. Thus, in CB, the early post-stroke period appears characterized by gradual - rather than sudden - loss of visual processing. Subacute training stops this degradation, and is dramatically more efficient at eliciting recovery than identical training in the chronic period. Finally, spontaneous improvements in subacutes appear restricted to luminance detection, whereas recovering discrimination abilities requires deliberate training. Simply stated, after an occipital stroke, "time is VISION". One Sentence SummaryThe first 3 months after an occipital stroke are characterized by a gradual - not sudden - loss of visual perceptual abilities and increased rehabilitative potential if visual discrimination training is administered in the blind field.

neuroscience↗

bioRxiv2018

Boosting learning efficacy with non-invasive brain stimulation in intact and brain-damaged humans

Numerous behavioral studies have shown that visual function can improve with training, although perceptual refinements generally require weeks to months of training to attain. This, along with questions about long-term retention of learning, limits practical and clinical applications of many such paradigms. Here, we show for the first time that just 10 days of visual training coupled with transcranial random noise stimulation (tRNS) over visual areas causes dramatic improvements in visual motion perception. Relative to control conditions and anodal stimulation, tRNS-enhanced learning was at least twice as fast, and, crucially, it persisted for 6 months after the end of training and stimulation. Notably, tRNS also boosted learning in patients with chronic cortical blindness, leading to recovery of motion processing in the blind field after just 10 days of training, a period too short to elicit enhancements with training alone. In sum, our results reveal a remarkable enhancement of the capacity for long-lasting plastic and restorative changes when a neuromodulatory intervention is coupled with visual training.

neuroscience↗