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Biology subjects

McMahon, K. L.

Publications and source records attributed to McMahon, K. L..

5 recordsLinked to original sources

From Smartphone Images to Musculoskeletal Models: Personalized Inertial Parameter Estimation

Every human body is different, however, current movement analysis does not reflect that, as it heavily relies on generic musculoskeletal models. Usually, these models are scaled to match the participants body segment lengths and body weight, but not taking individual body shape into account. This can lead to errors in the estimation of joint forces and torques, which are important to accurately estimate musculoskeletal variables. Thus, we developed a method to estimate body segment inertial parameters based on body hulls acquired via smartphone pictures. From the body hull, we infer the skeletal shape and pose, and then estimate the distribution of bone, lean, and fatty tissues. We then segment the body hull and assign each tissue type a density, which is used to calculate the body segment inertial parameters. To allow for the use of our method with existing data, we also introduce two new generic musculoskeletal models, which are based on the average standing body shapes. Validation using MRI-derived ground-truth models shows that our method creates participant-specific musculoskeletal models that are closer to the MRI-derived ground truth than scaled generic models. Additionally, we performed lab-based gait experiments to evaluate the effect of our method on residual forces and joint moments, where we found that our method leads to a reduction of residual forces of up to 14.9 % and a reduction of metabolic cost of up to 12.8 % when compared to generic musculoskeletal models. Our new generic models show similar joint moment outcomes, but less reduction of residual forces than the personalized models.

bioengineering↗

Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions

Research on genetic and environmental influences on brain function generally focuses on connections between brain areas. A different yet unexplored approach is to examine activity within local brain regions. We investigated the influence of genes and environmental effects on two specific measures of local brain function: Regional Homogeneity (ReHo) and fractional Amplitude of Low-Frequency Fluctuations (fALFF). Participants were drawn from a sample of adolescent twins on two occasions (mean ages 11.5 and 13.2 years, N = 278 and 248). Results showed that genetic and environmental factors influenced brain function in almost all 210 cortical regions examined. Moreover, genetic and common environmental factors influencing ReHo and fALFF values at wave 1 (9-14 years) also influenced values at wave 2 (10-16 years) for many regions. However, the influence of genetic and common environmental factors varied across the cortex, exhibiting different patterns in different regions. Furthermore, we found new (i.e., independent) genetic and environmental influences on brain activity at wave 2, again with regional patterns. Exploratory analyses found weak associations between anxiety and depressive symptoms and local brain function in several regions of the temporal lobe. These findings are consistent with similar studies of other resting-state functional MRI metrics (i.e., functional connectivity).

neuroscience↗

Reference curves for harmonizing multi-site regional diffusion MRI metrics across the lifespan

Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan, complementing the process of gray matter development and degeneration. Here, we create normative lifespan reference curves for global and regional WM microstructure by harmonizing diffusion MRI (dMRI)-derived data from ten public datasets (N = 40,898 subjects; age: 3-95 years; 47.6% male). We tested three harmonization methods on regional diffusion tensor imaging (DTI) based fractional anisotropy (FA), a metric of WM microstructure, extracted using the ENIGMA-DTI pipeline. ComBat-GAM harmonization provided multi-study trajectories most consistent with known WM maturation peaks. Lifespan FA reference curves were validated with test-retest data and used to assess the effect of the ApoE4 risk factor for dementia in WM across the lifespan. We found significant associations between ApoE4 and FA in WM regions associated with neurodegenerative disease even in healthy individuals across the lifespan, with regional age-by-genotype interactions. Our lifespan reference curves and tools to harmonize new dMRI data to the curves are publicly available as eHarmonize (https://github.com/ahzhu/eharmonize).

neuroscience↗

The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development

We describe the Queensland Twin Adolescent Brain (QTAB) dataset and provide a detailed methodology and technical validation to facilitate data usage. The QTAB dataset comprises multimodal neuroimaging, as well as cognitive and mental health data collected in adolescent twins over two sessions (session 1: N = 422, age 9-14 years; session 2: N = 304, 10-16 years). The MRI protocol consisted of T1-weighted (MP2RAGE), T2-weighted, FLAIR, high-resolution TSE, SWI, resting-state fMRI, DWI, and ASL scans. Two fMRI tasks were added in session 2: an emotional conflict task and a passive movie-watching task. Outside of the scanner, we assessed cognitive function using standardised tests. We also obtained self-reports of symptoms for anxiety and depression, perceived stress, sleepiness, pubertal development measures, and risk and protective factors. We additionally collected several biological samples for genomic and metagenomic analysis. The QTAB project was established to promote health-related research in adolescence.

neuroscience↗

The reliability and heritability of cortical folds and their genetic correlations across hemispheres.

The structure of the brains cortical folds varies considerably in human populations. Specific patterns of cortical variation arise with development and aging, and cortical traits are partially influenced by genetic factors. The degree to which genetic factors affect cortical folding patterning remains unknown, yet may be estimated with large-scale in-vivo brain MRI. Using multiple MRI datasets from around the world, we estimated the reliability and heritability of sulcal morphometric characteristics including length, depth, width, and surface area, for 61 sulci per hemisphere of the human brain. Reliability was assessed across four distinct test-retest datasets. We meta-analyzed the heritability across three independent family-based cohorts (N > 3,000), and one cohort of largely unrelated individuals (N~9,000) to examine the robustness of our findings. Reliability was high (interquartile range for ICC: 0.65-0.85) for sulcal metrics. Most sulcal measures were moderately to highly heritable (heritability estimates = 0.3-0.7). These genetic influences vary regionally, with the earlier forming sulci having higher heritability estimates. The central sulcus, the subcallosal and the collateral fissure were the most highly heritable regions. For some frontal and temporal sulci, left and right genetic influences did not completely overlap, suggesting some lateralization of genetic effects on the cortex.

genetics↗