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Martin-Cuadrado, A.-B.

Publications and source records attributed to Martin-Cuadrado, A.-B..

2 recordsLinked to original sources

Population dynamics of Pelagibacterales clonal lineages: ecological-consortia and frequency modulation

Pelagibacterales gMED is the dominant epipelagic genomospecies in the western Mediterranean Sea. We used the O-chain biosynthesis gene clusters, OBCs, as clonal barcodes to analyse strain-level population structure. In total, 385 OBC-defined clonal lineages were tracked across Mediterranean metagenomes spanning 14 years and depths from 5 to 90 m within the photic zone, with between 128 and 336 detected per metagenome. The relative conservation of dominant OBC types across years, seasons, and geographic locations indicated a persistently high and stable clonal diversity. Abundance distributions were log-normal in all metagenomes -- the canonical signature of bet-hedging portfolio dynamics. Co-varying consortia of clonal lineages were detected, identifying ecologically coherent guilds whose relative abundances fluctuate in concert across environmental gradients, particularly depth during the stratified season. Consortia membership showed no correlation with core-genome phylogeny, indicating convergent ecological adaptation independently of ancestry. Our work reveals another layer of complexity below the community level, which together with its modulation, provides the gMED population with a robust and versatile genetic repertoire for the degradation of dissolved organic matter under the fluctuating conditions of the epipelagic ocean. We have named this mechanistic model frequency-modulation (FM).

microbiology↗

A host recognition module shared among distant Alteromonas bacteriophage families features tail fibers with transient chaperone caps

The host recognition modules encoding the injection machinery and receptor binding proteins (RBPs) of bacteriophages are variable genomic units predisposed to mutation and recombination to maintain infectivity toward co-evolving bacterial hosts. In this study, we reveal how Alteromonas mediterranea schitovirus A5 shares its host recognition module, including tail fiber (TF) and cognate chaperone, with phages from distantly related families including Alteromonas myovirus, V22. While the chaperone of V22 is essential for producing active TFs, here we demonstrate production of functional A5 TFs regardless of chaperone co-expression. AlphaFold-generated models of TF and chaperone pairs from phages A5, V22, and other Alteromonas phages reveal how amino acid insertions within both A5-like proteins results in a knob domain duplication in the TF and a {beta}-hairpin "tentacle" extension of the chaperone. These structural modifications are linked to chaperone dependency differences between the A5 and V22 TFs. Structural similarity between the chaperones and intramolecular chaperone domains of other phage RBPs suggests an additional function of these chaperones as transient TF "caps". Finally, our identification of homologous host recognition modules used by morphologically distinct phages implies that HGT and recombination events between unrelated phages may be a more common process than previously thought among Caudoviricetes phages.

microbiology↗