Biology subjects

Manore, C. A.

Publications and source records attributed to Manore, C. A..

3 recordsLinked to original sources

bioRxiv2021

A Process-Based Model with Temperature, Water, and Lab-derived Data Improves Predictions of Daily Mosquito Density

While the number of human cases of mosquito-borne diseases has increased in North America in the last decade, accurate modeling of mosquito population density has remained a challenge. Longitudinal mosquito trap data over the many years needed for model calibration is relatively rare. In particular, capturing the relative changes in mosquito abundance across seasons is necessary for predicting the risk of disease spread as it varies from year to year. We developed a process-based mosquito population model that captures life-cycle egg, larva, pupa, adult stages, and diapause for Culex pipiens and Culex restuans mosquito populations. Mosquito development through these stages is a function of time, temperature, daylight hours, and aquatic habitat availability. The time-dependent parameters are informed by both laboratory studies and mosquito trap data from the Greater Toronto Area. The model incorporates city-wide water-body gauge and precipitation data as a proxy for aquatic habitat. This approach accounts for the nonlinear interaction of temperature and aquatic habitat variability on the mosquito life stages. We demonstrate that the full model predicts the yearly variations in mosquito populations better than a statistical model using the same data sources. This improvement in modeling mosquito abundance can help guide interventions for reducing mosquito abundance in mitigating mosquito-borne diseases like the West Nile virus.

ecology↗

bioRxiv2019

Co-infections by non-interacting pathogens are not independent and require new tests of interaction

If pathogen species, strains or clones do not interact, intuition suggests the proportion of co-infected hosts should be the product of the individual prevalences. Independence consequently underpins the wide range of methods for detecting pathogen interactions from cross-sectional survey data. However, the very simplest of epidemiological models challenge the underlying assumption of statistical independence. Even if pathogens do not interact, death of co-infected hosts causes net prevalences of individual pathogens to decrease simultaneously. The induced positive correlation between prevalences means the proportion of co-infected hosts is expected to be higher than multiplication would suggest. By modeling the dynamics of multiple non-interacting pathogens, we develop a pair of novel tests of interaction that properly account for non-independence. Our tests allow us to reinterpret data from previous studies including pathogens of humans, plants, and animals. Our work demonstrates how methods to identify interactions between pathogens can be updated using simple epidemic models.

epidemiology↗

bioRxiv2018

Modeling Zika Virus Spread in Colombia Using Google Search Queries and Logistic Power Models

Public health agencies generally have a small window to respond to burgeoning disease outbreaks in order to mitigate the potential impact. There has been significant interest in developing forecasting models that can predict how and where a disease will spread. However, since clinical surveillance systems typically publish data with a lag of two or more weeks, there is a need for complimentary data streams that can close this gap. We examined the usefulness of Google Trends search data for analyzing the 2016 Zika epidemic in Colombia and evaluating their ability to predict its spread. We calculated the correlation and the time delay between the reported case data and the Google Trends data using variations of the logistic growth model, and showed that the data sets were systematically offset from each other, implying a lead time in the Google Trends data. Our study showed how Internet data can potentially complement clinical surveillance data and may be used as an effective early detection tool for disease outbreaks.

epidemiology↗