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Maldonado, F.

Publications and source records attributed to Maldonado, F..

2 recordsLinked to original sources

Decoding Internal Decision Making During Reverse Engineering Tasks

Neural decoding is often limited to tasks with known stimuli and limited response options . Real world tasks, however, are often completely stimulus free with unconstrained user response possibilities. Real time decoding of internal decision making would allow for more complex and interactive Huma Machine Teaming in a way that is not currently possible. To address this problem, we present here a novel method of decoding moments of recognition and their associated internal value judgments in the context of highly complex software reverse engineering tasks. This is done through a combination of P300 detection (a neural marker of recognition) and the Engagement Index (a ratio of neural band powers) to determine whether an item has been identified as relevant to the task (to be further explored) or irrelevant to the task (to be quickly ignored). Artificial neural networks were trained to identify P300s in each subject during the reverse engineering tasks. Dimensionality reduction of neural data during the tasks showed the existence of separately clustering subgroups of P300s with differences in Engagement Index. Subgroups of P300s differentiated by Engagement were further verified as distinct groupings with pupil dilation and user behavior metrics. This decoded information could be used to aid in the reverse engineering process via cognitive offloading of the users own decision making on to the visual interface in a completely automated and personalized fashion. This represents a significant advance in domain of real-time neural decoding, and opens up many further possibilities for usage in a broad range of intelligent human systems integration applications.

neuroscience↗

Longitudinal prediction of outcome in idiopathic pulmonary fibrosis using automated CT analysis

AIMSTo evaluate computer-derived (CALIPER) CT variables against FVC change as potential drug trials endpoints in IPF.\n\nMETHODS71 Royal Brompton Hospital (discovery cohort) and 23 Mayo Clinic Rochester and 24 St Antonius Hospital Nieuwegein IPF patients (validation cohort) were analysed. Patients had two CTs performed 5-30 months apart, concurrent FVC measurements and were not exposed to antifibrotics (to avoid confounding of mortality relationships from antifibrotic use). Cox regression analyses (adjusted for patient age and gender) evaluated outcome for annualized FVC and CALIPER vessel-related structures (VRS) change and examined the added prognostic value of thresholded VRS changes beyond standard FVC change thresholds.\n\nRESULTSChange in VRS was a stronger outcome predictor than FVC decline when examined as continuous variables, in discovery and validation cohorts. When FVC decline ([≥]10%) and VRS thresholds were examined together, the majority of VRS change thresholds independently predicted outcome, with no decrease in model fit. When analysed as co-endpoints, a VRS threshold of [≥]0{middle dot}40 identified 30% more patients reaching an endpoint than a [≥]10% FVC decline threshold alone.\n\nCONCLUSIONSChange in VRS is a strong predictor of outcome in IPF and can increase power in future drug trials when used as a co-endpoint alongside FVC change.\n\nEthics committee approvalApproval for this study of clinically indicated CT and pulmonary function data was obtained from Liverpool Research Ethics Committee (Reference: 14/NW/0028) and the Institutional Ethics Committee of the Royal Brompton Hospital, Mayo Clinic Rochester and St. Antonius Hospital, Nieuwegein. Informed patient consent was not required.\n\nTake home messageChange in the vessel-related structures, a computer-derived CT variable, is a strong predictor of outcome in idiopathic pulmonary fibrosis and can increase power in future drug trials when used as a co-endpoint alongside forced vital capacity change.

bioinformatics↗