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Makoundou, P.

Publications and source records attributed to Makoundou, P..

8 recordsLinked to original sources

Tis But a Scratch! Negligible fitness costs of AalDV2 infection in Aedes albopictus under fluctuating temperatures and implications for viral biocontrol

Aedes albopictus is a major arboviral vector whose global expansion, driven by human activities and climate change, poses a growing public health concern for a number of neglected tropical diseases in both tropical and temperate regions. As a poikilotherm, its biology and population dynamics are strongly influenced by temperature, thereby shaping disease transmission. To thwart and control its geographic expansion, effective vector control strategies are increasingly critical. Densoviruses (DVs), such as AalDV2, are being explored as mosquito viral biocontrol agents due to their restricted host range and ability to disseminate through oviposition sites. However, the influence of environmental parameters on the interactions between Ae. albopictus and AalDV2 remains poorly understood. This makes their performance under realistic, fluctuating thermal regimes difficult to estimate. In this study, we investigated the combined effects of temperature and AalDV2 exposure on Ae. albopictus survival and development across its full life cycle. Mosquitoes were reared under fluctuating temperature regimes (26-28{degrees}C and 32-34{degrees}C, 12:12 day-night cycles) and exposed to AalDV2 or a control treatment. Chronic exposure to 32-34{degrees}C significantly reduced overall survival, decreasing median lifespan by approximately 10 days (HR=2.21, p=0.0018), with a deleterious effect increasing over time. It extended aquatic lifespan and increased pupal mortality. It also reduced adult lifespan in both sexes with a stronger effect in females. AalDV2 exposure had no significant effect on overall survival, stage-specific mortality, or adult lifespan. However, a significant interaction between viral exposure and thermal stress was detected on aquatic lifespan: AalDV2-exposed females showed further extended larval and pupal development specifically under the 32-34{degrees}C regime, without any effect on survival. These results indicate that the biocontrol potential of AalDV2 cannot be assessed independently of thermal context: while lethal effects were absent under both fluctuating regimes, the prolongation of aquatic development by the virus under thermal stress may have indirect consequences for mosquito population dynamics that warrant further investigation. Author SummaryThe tiger mosquito Aedes albopictus is among the most invasive species worldwide including in temperate areas and a major vector of dengue, chikungunya, and Zika viruses. Concerns with this species are growing in the context of climate change and effective vector control strategies are increasingly critical. Densoviruses, such as AalDV2, are small DNA viruses that infect mosquitoes and are being explored as potential biocontrol agents because of their restricted host range and ability to spread through shared breeding sites and kill mosquito aquatic stages. However, the understanding of influence of the environmental conditions such as temperature on the effectiveness of these viruses remains incomplete. Here, we investigated the combined effects of fluctuating temperatures (26-28{degrees}C and 32-34{degrees}C day/night cycles) and AalDV2 exposure on mosquitoes throughout their entire lifespan, from larva to adult death. Our results show that chronic exposure to high fluctuating temperatures strongly reduces mosquito survival, mainly by increasing mortality during pupation and shortening adult lifespan. While AalDV2 exposure did not significantly affect survival or mortality under either temperature regime, a significant interaction between viral exposure and thermal stress was detected: AalDV2-exposed females showed prolonged aquatic development specifically under the high temperature regime (32-34{degrees}C). This result demonstrates that temperature shapes the outcome of host-virus interactions even in the absence of lethal effects, and that realistic thermal variability must be incorporated into the evaluation of densovirus-based biocontrol strategies.

evolutionary biology↗

Stranger Swings: Temperature-Dependent Upsides and Downsides of a Densovirus in Aedes albopictus

Vector-borne diseases remain a significant global health concern, with the invasive mosquito Aedes albopictus playing a key role in the transmission of arboviruses including dengue, chikungunya, and Zika viruses. As this species expands in novel territories, effective vector control strategies are increasingly critical. Densoviruses (DVs) have emerged as potential biological control agents, either through direct pathogenic effects on mosquito populations or via paratransgenesis. However, the influence of combined environmental factors, such as temperature and densovirus infection on mosquito life-history traits remains largely unexplored. In this study, we investigated the effects of different temperatures (28{degrees}C, 31{degrees}C, and 34{degrees}C) and exposure to the densovirus AalDV2 on the survival of Ae. albopictus and on several mosquito life-history traits including its development time, size and symmetry at adult stage. Larvae were individually reared under controlled conditions and exposed to AalDV2 or a control treatment. Temperature had a strong nonlinear effect on survival, with dramatic mortality increases at 34{degrees}C. Unexpectedly, AalDV2-infected larvae showed significantly higher survival than controls at this extreme temperature, suggesting a protective effect under thermal stress. Across all temperatures, viral infection delayed pupation in a sex-dependent manner, with females experiencing greater delays and reduced adult wing size. Quantitative PCR revealed high infection rates (>96%) across all conditions with a viral load increasing with higher temperature in a sex-dependent manner. Our findings reveal a paradoxical outcome: while AalDV2 imposes fitness costs through delayed development and reduced body size, it confers an unexpected survival advantage at the extreme temperature. This represents the first documentation of temperature-dependent protective effects by an entomopathogenic virus in mosquitoes, challenging conventional assumptions about pathogen impacts. These results have critical implications for vector biocontrol strategies in a warming climate, as densovirus deployment could inadvertently enhance mosquito resilience in heat-stressed regions. Further research is needed to elucidate the underlying mechanisms and assess the impact on mosquito population dynamics.

evolutionary biology↗

Recombination, truncation and horizontal transfer shape the diversity of cytoplasmic incompatibility patterns

Wolbachia are endosymbiotic bacteria inducing various reproductive manipulations of which cytoplasmic incompatibility (CI) is the most common. CI leads to reduced embryo viability in crosses between males carrying Wolbachia and uninfected females or those carrying an incompatible symbiont strain. In the mosquito Culex pipiens, the Wolbachia wPip causes highly complex crossing patterns. This complexity is linked to the amplification and diversification of the CI causal genes, cidA and cidB, with polymorphism located in the CidA-CidB interaction regions. We previously showed correlations between the identity of gene variants and CI patterns. However, these correlations were limited to specific crosses, and it is still unknown whether cid gene polymorphism in males and females Wolbachia can explain and predict the wide range of crossing types observed in C. pipiens. Taking advantage of a new method enabling full-gene acquisition, we sequenced complete cid repertoires from 45 wPip strains collected worldwide. We demonstrated that the extensive diversity of cid genes arises from recombination and horizontal transfers. We uncovered further cidB polymorphism outside the interface regions and strongly correlated with CI patterns. Most importantly, we showed that in every wPip genome, all but one cidB variant are truncated. Truncated cidBs located in palindromes are partially or completely deprived of their deubiquitinase domain, crucial for CI. The identity of the sole full-length cidB variant seems to dictate CI patterns, irrespective of the truncated cidBs present. Truncated CidBs exhibit reduced toxicity and stability in Drosophila cells, which potentially hinders their loading into sperm, essential for CI induction.

evolutionary biology↗

Intra-lineage microevolution of Wolbachia leads to the emergence of new cytoplasmic incompatibility patterns

Mosquitoes of the Culex pipiens complex are worldwide vectors of arbovirus, filarial nematode, and avian malaria agents. In these hosts, the endosymbiotic bacteria Wolbachia induce cytoplasmic incompatibility (CI), that is, reduced embryo viability in so-called incompatible crosses. Wolbachia infecting Culex pipiens (wPip) cause CI patterns of unparalleled complexity, associated with the amplification and diversification of cidA and cidB genes, with up to six different gene copies described in a single wPip genome. By repeating crosses between Culex isofemale lines over 17 years, we documented the emergence of a new compatibility type. Using a new sequencing method adapted to multigene families to acquire cid genes, we showed that some wPip genomes lost specific cidA gene copies, thus giving rise to several sub-lineages segregating in the same cage. By linking phenotypic changes to their underlying genotypic bases, we showed that gene copies that are key for CI phenotypes originated from recombinations, not point mutations. We revealed how new CI patterns could emerge as part of a two-step process: first, local changes take place in the CI repertoires while maintaining compatibility with the surrounding mosquitoes, and then migration and secondary contact occur with the incompatible lines.

evolutionary biology↗

Striking allelic diversity despite structural homogeneity of ace-1 duplications in Anopheles mosquitoes

A. gambiae s.l. has been the target of intense insecticide treatment since the mid-XXth century to try and control malaria, and a substitution in the ace-1 locus allowing resistance to organophosphate and carbamates insecticides has been rapidly selected for. Since then, several duplications of the ace-1 locus have been found in A. gambiae s.l. populations. They associate either several resistance copies (homogeneous duplications) or both resistance and susceptible copies (heterogeneous duplications). Heterogeneous duplications confer an intermediate trade-off between resistance in presence of insecticide and disadvantage in their absence. So far, and in striking contrast with C. pipiens mosquitoes, a single heterogeneous duplication had been describe in A. gambiae populations. We use an innovative approach, combining information from long and short read sequencing with Sanger sequencing to precisely identify and describe at least nine different heterogeneous duplications in A. gambiae. We further show that these alleles share the exact same structure than the previously identified heterogeneous and homogeneous duplications, namely 203-kb tandem amplifications with conserved breakpoints. Our study sheds a new light on the origin and maintenance of these alleles in A. gambiae populations, and pushes one step further the striking evolutionary convergence with C. pipiens mosquitoes.

evolutionary biology↗

Nanopore sequencing enables multigenic family reconstruction despite highly frequent PCR-induced recombination

This study developed a new bioinformatics pipeline to acquire all the different copies of multi-copy gene families based on Oxford Nanopore Technologies sequencing of PCR products. We used this pipeline to acquire the sequences of highly similar copies of the cidA and cidB genes present in the genomes of Wolbachia pipientis (wPip) bacteria infecting the cells of Culex pipiens mosquitoes. The approach is based on read mapping, SNP calling and haplotyping, using our already wide existing reference database for the cid genes obtained by cloning and Sanger sequencing. We addressed problems commonly faced when using mapping approaches for multi-copy gene families with highly similar variants (or haplotypes). In addition, we confirmed that PCR amplification causes frequent chimeras which have to be carefully considered when working on families of recombinant genes. We tested the robustness of the pipeline through a combination of analyses of simulated reads and of gene sequence acquisitions through cloning and Sanger sequencing. For genes of which the haplotype cannot be reconstructed from short reads sequencing, this pipeline confers a high throughput acquisition, gives reliable results as well as insights of the relative copy numbers of the different variants.

genomics↗

The mosquito microbiome includes habitat-specific but rare symbionts

Microbial communities are known to influence mosquito lifestyles by modifying essential metabolic and behavioral processes that affect reproduction, development, immunity, digestion, egg survival, and ability to transmit pathogens. Many studies have used 16S rRNA gene amplicons to characterize mosquito microbiota and investigate factors that influence host-microbiota dynamics. However, a relatively low taxonomic resolution due to clustering methods based on arbitrary threshold and the overall dominance of Wolbachia or Asaia populations obscured the investigation of rare members of mosquito microbiota in previous studies. Here, we used high resolution Shannon entropy-based oligotyping approaches to analyze the microbiota of Culex pipiens, Culex quinquefasciatus and Aedes individuals from continental and overseas regions in Southern France and Guadeloupe as well as from laboratories with or without antibiotics treatment. Our experimental design that resulted in a series of mosquito samples with a gradient of Wolbachia density and relative abundance along with high-resolution analyses of amplicon sequences enabled the recovery of a robust signal from typically less accessible bacterial taxa. Our data confirm species-specific mosquito-bacteria associations with geography as a primary factor that influences bacterial community structure. But interestingly, they also reveal co-occurring symbiotic bacterial variants within single individuals for both Elizabethkingia and Erwinia genera, distinct and specific Asaia and Chryseobacterium in continental and overseas territories and a putative rare Wolbachia variant. Overall, our study reveals the presence of previously-overlooked microdiversity and multiple closely related symbiotic strains within mosquito individuals with a remarkable habitat-specificity.

microbiology↗