Biology subjects

Maiti, B.

Publications and source records attributed to Maiti, B..

2 recordsLinked to original sources

bioRxiv2023

SARS-COV-2 Spike Protein Fragment eases Amyloidogenesis of α-Synuclein

Parkinsons Disease is accompanied by presence of amyloids in the brain formed of -synuclein chains. Correlation between COVID-19 and the onset of Parkinsons disease let to the idea that amyloidogenic segments in SARS-COV-2 proteins can induce aggregation of -synuclein. Using molecular dynamic simulations, we show that the fragment FKNIDGYFKI of the spike protein, which is unique for SARS-COV-2, shifts preferentially the ensemble of -synuclein monomer towards rod-like fibril seeding conformations, and at the same time stabilizes differentially this polymorph over the competing twister-like structure. Our results are compared with earlier work relying on a different protein fragment that is not specific for SARS-COV-2.

biochemistry↗

bioRxiv2023

Human Amylin in the Presence of SARS-COV-2 Protein Fragments

Covid-19 can lead to the onset of type-II diabetes which is associated with aggregation of islet amyloid polypeptides, also called amylin. Using molecular dynamics simulations, we investigate how the equilibrium, between amylin monomers in its functional form and fibrils associated with diabetes, is altered in presence of SARS-COV-2 protein fragments. For this purpose, we study the interaction between the fragment SFYVYSRVK of the Envelope protein or the fragment FKNIDGYFKI of the Spike protein with the monomer and two amylin fibril models. Our results are compared with earlier work studying such interactions for two different proteins.

biophysics↗