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Biology subjects

Maggi, E.

Publications and source records attributed to Maggi, E..

2 recordsLinked to original sources

A Semi-Dry, Visually Comfortable c-VEP BCI with Short Calibration, Conservative Idle-State Behavior, and a VR Proof of Concept

Background and Objectives: Code-modulated visual evoked potentials (c-VEPs) provide fast and reliable control signals for reactive brain-computer interfaces (rBCIs). However, deployment beyond laboratories remains limited by visually intrusive stimulation, reliance on wet electroencephalography (EEG), and false activations during non-control periods. We introduce a usability-oriented c-VEP rBCI combining low-salience textured stimulation, slow flashing codes, asynchronous evidence accumulation, and semi-dry EEG acquisition. Methods: Thirty participants evaluated the system on a standard screen using an 11-class keypad typing task. Two identical online typing sessions were separated by a 2-min video-viewing period serving as an explicit idle condition. Feasibility was then assessed in virtual reality (VR) through a proof-of-concept shell-game task involving head movements and immersive rendering constraints. Visual comfort, peripheral distraction, and fatigue were assessed subjectively in both conditions. Results: In the keypad task, the system achieved 99.8% accuracy with 33 s of calibration data and a mean decoding time of 4.3 s. No spurious commands occurred during the tested 2-min idle condition. In VR, online accuracy reached 100%, with a mean decoding time of 5.6 s. Participants reported high visual comfort and minimal peripheral distraction in both conditions, although fatigue was higher in VR. Conclusion: The proposed c-VEP rBCI combines short calibration, high accuracy, comfortable stimulation, semi-dry EEG, and asynchronous decision-making. Performance during the explicit idle condition and VR implementation support the feasibility of wearable and practical c-VEP systems for self-paced interaction beyond laboratory environments. These findings encourage evaluation in longer idle periods and real-world tasks.

neuroscience↗

Aneuvis: Web-based exploration of numerical chromosomal variation in single cells

MotivationAberrations in chromosomal copy number are one of the most common molecular features observed in cancer. Quantifying the degree of numerical chromosomal variation in single cells across a population of cells is of interest to researchers studying whole chromosomal instability (W-CIN). W-CIN, a state of high numerical chromosomal variation, contributes to treatment resistance in cancer.\n\nResultsHere, we introduce aneuvis, a web application that allows users to determine whether numerical chromosomal variation exists between experimental treatment groups. The web interface allows users to upload molecular cytogenetic or processed whole-genome sequencing data in a cell-by-chromosome matrix format and automatically generates visualizations and summary statistics that reflect the degree of numeric chromosomal variability. Aneuvis is the first user-friendly web application to help researchers identify the genetic and environmental perturbations that promote numerical chromosomal variation.\n\nAvailability and ImplementationAneuvis is freely available as a web application at https://dpique.shinyapps.io/aneuvis/. Website implemented using Shiny version 1.0.5 with all major browsers supported. All source code for the application is available at https://github.com/dpique/aneuvis.

bioinformatics↗