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Biology subjects

Macfarlane, F.

Publications and source records attributed to Macfarlane, F..

2 recordsLinked to original sources

BeeSAM2: detecting bees in cherry flowers using timelapse images and foundational models

Bees perform important pollination services in fruit crops such as cherry. Growers will often bring in bees to supplement natural pollinators. Monitoring the performance of these pollinators is important to understand the impact of augmenting pollinators on fruit yield particularly in relation to June drop which is a major cause of yield instability in the cherry industry. Timelapse imaging plus automated image analysis methods is a valuable tool in studying the role of bee pollination in fruit set. Timelapse cameras allow for continuous monitoring of the flowers, but manual analysis of the generated footage is very time consuming. We have developed a novel method of detecting bees in time lapse images, called BeeSAM2. This exploits both the zero shot detector Grounding Dino and the foundational model Segment Anything 2. Promising results are achieved with the method able to detect the bumblebee Bombus terrestris in images with a recall of 0.959 and precision of 0.991. These results are accurate enough to deploy our method to quantify bee activity in cherry plantations, advancing the ability of researchers to monitor bee interactions with flowers with a significant time saving over manual analysis of timelapse footage.

ecology↗

Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes pain, swelling and stiffness in the joints, and negatively impacts the life of affected patients. The disease does not have a cure yet, as there are still many aspects of this complex disorder that are not fully understood. While mathematical models can shed light on some of these aspects, to date there are few such models that can be used to better understand the disease. As a first step in the mechanistic understanding of RA, in this study we introduce a new hybrid mathematical modelling framework that describes pannus formation in a small proximal interphalangeal (PIP) joint. We perform numerical simulations with this new model, to investigate the impact of different levels of immune cells (macrophages and fibroblasts) on the degradation of bone and cartilage. Since many model parameters are unknown and cannot be estimated due to a lack of experiments, we also perform a sensitivity analysis of model outputs to various model parameters (single parameters or combinations of parameters). Finally, we discuss how our model could be applied to investigate current treatments for RA, for example, methotrexate, TNF-inhibitors or tocilizumab, which can impact different model parameters.

immunology↗