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Biology subjects

Lundberg, P.

Publications and source records attributed to Lundberg, P..

6 recordsLinked to original sources

An extended Kalman filter for large-volume path positioning of aquatic animals within acoustic telemetry arrays

Acoustic telemetry is a core methodology for collecting fine-scale movement data for aquatic animals. When telemetry receivers are set up in closely spaced arrays with overlapping detection ranges, the detection times of a tagged animal can be used to estimate its position and movement paths. In practice, estimating these paths can be challenging. Traditional time-difference-of-arrival methods generally provide positioning accuracy too poor for inferring fine-scale behaviours, while more robust state-space positioning models can be computationally intensive and practically infeasible to run on large datasets. Here, a novel telemetry positioning method is presented where time-of-arrival positioning is implemented as a state-space model within an extended Kalman filter. The resulting model, termed EK-TOA, provides closed-form solutions to track estimation. Simulated datasets of fish movement within a 2D telemetry array are used to verify the models performance and a real case study is provided where EK-TOA is utilized for the long-term tracking of a tagged fish. In comparison to currently available positioning models, EK-TOA provides a fast and accurate solution for tracking fine-scale movement behaviours of aquatic animals over long, continuous periods of time.

ecology↗

Absolute measures of time-difference-of-arrival positioning error in underwater acoustic telemetry setups

This brief communication presents two solutions for calculating absolute measures of error from time-difference-of-arrival (TDOA) positioning in underwater acoustic telemetry arrays. First, a Monte Carlo estimation of TDOA positioning error is derived. Next, a computationally inexpensive, approximate solution to the Monte Carlo method is presented. This approximate solution is achieved by solving the Jacobian of a closed-form TDOA positioning model. The positioning error covariance matrix returned from either method can then be used to report the accuracy of TDOA positions or utilized in state-space positioning models. Finally, calculations of the expected radial error are shown which serves as a simple summary statistic for reporting positioning error in real units.

ecology↗

A Physiologically Based Digital Twin for Alcohol Consumption - Predicting Real-life Drinking Responses and Long-term Plasma PEth

Alcohol consumption is associated with a wide variety of preventable health complications and is a major risk factor for all-cause mortality in the age group 15-47 years. To reduce dangerous drinking behavior, eHealth applications have shown promise. A particularly interesting potential lies in the combination of eHealth apps with mathematical models. However, existing mathematical models do not consider real-life situations, such as combined intake of meals and beverages, and do not connect drinking to clinical markers, such as phosphatidylethanol (PEth). Herein, we present such a model which can simulate real-life situations and connect drinking to long-term markers. The new model can accurately describe both estimation data according to a {chi}2-test (187.0 < T{chi}2 = 226.4) and independent validation data (70.8 < T{chi}2 =93.5). The model can also be personalized using anthropometric data from a specific individual and can thus be used as a physiologically-based digital twin. This twin is also able to connect short-term consumption of alcohol to the long-term dynamics of PEth levels in the blood, a clinical biomarker of alcohol consumption. Here we illustrate how connecting short-term consumption to long-term markers allows for a new way to determine patient alcohol consumption from measured PEth levels. An additional use case of the twin could include the combined evaluation of patient-reported AUDIT forms and measured PEth levels. Finally, we integrated the new model into an eHealth application, which could help guide individual users or clinicians to help reduce dangerous drinking.

systems biology↗

A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects

AimsThe increased prevalence of insulin resistance is one of the major health risks in society today. Insulin resistance involves both short-term dynamics, such as altered meal responses, and long-term dynamics, such as development of type 2 diabetes. Insulin resistance also occurs on different physiological levels, ranging from disease phenotypes to organ-organ communication and intracellular signaling. To better understand the progression of insulin resistance, an analysis method is needed that can combine different timescales and physiological levels. One such method is digital twins, consisting of combined mechanistic multi-scale and multi-level mathematical models. We have previously developed a multi-level model for short-term glucose homeostasis and intracellular insulin signaling, and there exists long-term weight regulation models. However, no one has combined these kinds of models into an interconnected, multi-level and multi-timescale digital twin model. Herein, we present a first such multi-scale digital twin for the progression of insulin resistance in humans. MethodsThe model is based on ordinary differential equations representing biochemical and physiological processes, in which unknown parameters were fitted to data using a MATLAB toolbox. ResultsThe connected twin correctly predicts independent data from a weight increase study, both for weight-changes, for fasting plasma insulin and glucose levels, as well as for intracellular insulin signaling. Similarly, the model can predict independent weight-change data in a weight loss study, involving diet and the weight loss drug topiramate. These independent validation tests are confirmed by a chi-square test (() = 4.8 < 21 = 2, (12,0.05)). In both these cases, the model can also predict non-measured variables, such as activity of intracellular intermediaries, glucose tolerance responses, and organ fluxes. ConclusionsWe present a first multi-level and multi-timescale model, describing dynamics on the whole-body, organ and cellular levels, ranging from minutes to years. This model constitutes the basis for a new digital twin technology, which in the future could potentially be used to aid medical pedagogics and increase motivation and compliance and thus aid in prevention and treatment of insulin resistance.

systems biology↗

Digital twin predicting diet response before and after long-term fasting

Today, there is great interest in diets proposing new combinations of macronutrient compositions and fasting schedules. Unfortunately, there is little consensus regarding the impact of these different diets, since available studies measure different sets of variables in different populations, thus only providing partial, non-connected insights. We lack an approach for integrating all such partial insights into a useful and interconnected big picture. Herein, we present such an integrating tool. The tool uses a novel mathematical model that describes mechanisms regulating diet-response and fasting metabolic fluxes, both for organ-organ crosstalk, and inside the liver. The tool can mechanistically explain and integrate data from several clinical studies, and correctly predict new independent data, including data from a new clinical study. Using this model, we can predict non-measured variables, e.g. hepatic glycogen and gluconeogenesis, and we can quantify personalized expected differences in outcome for any diet. This constitutes a new digital twin technology.

systems biology↗

Next-generation ultrasonic recorders facilitate effective bat activity and distribution monitoring by citizen scientists

Time and budgetary resources are often a limiting factor in the collection of large-scale ecological data. If data collected by citizen scientists were comparable to data collected by researchers, it would allow for more efficient data collection over a broad geographic area. Here, we compare the quality of data on bat activity collected by citizens (high school students and teachers) and researchers. Both researchers and citizen scientists used the same comprehensive instructions when choosing study sites. We found no differences in total bat activity minutes recorded by citizens and researchers. Instead, citizen scientists collected data from a wider variety of habitats than researchers. Involvement of citizens also increased the geographical coverage of data collection, resulting in the northernmost documentation of the Nathusiuss pipistrelle so far in Finland. Therefore, bat research can benefit from the use of citizen science when participants are given precise instructions and calibrated data collection equipment. Citizen science projects also have other far-reaching benefits, increasing, for example, the scientific literacy and interest in natural sciences of citizens. Involving citizens in science projects also has the potential to enhance their willingness to conserve nature. Open Research StatementData are not yet provided, but will uploaded Dryad upon publication.

ecology↗