Biology subjects

Lord, C.

Publications and source records attributed to Lord, C..

3 recordsLinked to original sources

bioRxiv2018

Minimum Information for Reusable Arthropod Abundance Data (MIReAAD)

Introduction Introduction Discussion Conclusion References Arthropods play a dominant role in the dynamics of practically all natural and human-modified terrestrial ecosystems1-3, and have significant economic and health effects. For example, certain insects provide significant economic benefits (e.g. pollination) exceeding $57 billion a year to the United States alone4. Meanwhile, invasive insects cost an estimated $70 billion dollars per year globally5 and insect pests may reduce agricultural harvests by up to 16%, with an equal amount of further losses of harvested goods6. Particularly noteworthy is a subset of arthropods that are disease vectors, transmitting pathogens to and between animals as well as plan ...

ecology↗

bioRxiv2017

The Healthy Brain Network Biobank: An open resource for transdiagnostic research in pediatric mental health and learning disorders

Technological and methodological innovations are equipping researchers with unprecedented capabilities for detecting and characterizing pathologic processes in the developing human brain. As a result, ambitions to achieve clinically useful tools to assist in the diagnosis and management of mental health and learning disorders are gaining momentum. To this end, it is critical to accrue large-scale multimodal datasets that capture a broad range of commonly encountered clinical psychopathology. The Child Mind Institute has launched the Healthy Brain Network (HBN), an ongoing initiative focused on creating and sharing a biobank of data from 10,000 New York area participants (ages 5-21). The HBN Biobank houses data about psychiatric, behavioral, cognitive, and lifestyle phenotypes, as well as multimodal brain imaging (resting and naturalistic viewing fMRI, diffusion MRI, morphometric MRI), electroencephalography, eye-tracking, voice and video recordings, genetics, and actigraphy. Here, we present the rationale, design and implementation of HBN protocols. We describe the first data release (n = 664) and the potential of the biobank to advance related areas (e.g., biophysical modeling, voice analysis).

neuroscience↗

bioRxiv2017

Damaging Mutations are Associated with Diminished Motor Skills and IQ in Children on the Autism Spectrum

In individuals with Autism Spectrum Disorder (ASD), de novo mutations have previously been shown to be significantly correlated with lower IQ, but not with the core characteristics of ASD: deficits in social communication and interaction, and restricted interests and repetitive patterns of behavior. We extend these findings by demonstrating in the Simons Simplex Collection that damaging de novo mutations in ASD individuals are also significantly and convincingly correlated with measures of impaired motor skills. This correlation is not explained by a correlation between IQ and motor skills. We find that IQ and motor skills are distinctly associated with damaging mutations and, in particular, that motor skills are a more sensitive indicator of mutational severity, as judged by the type and its gene target. We use this finding to propose a combined classification of phenotypic severity: mild (little impairment of both), moderate (impairment mainly to motor skills) and severe (impairment of both).

genetics↗