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Larson, J.

Publications and source records attributed to Larson, J..

2 recordsLinked to original sources

Bioinformatic analysis reveals mechanisms underlying parasitoid venom evolution and function

Introduction Introduction Methods Results and Discussion Conclusions References Parasitoid wasps are a numerous and diverse group of insects that obligately infect other arthropod species. These wasps lay their eggs either on the surface or within the body cavity of their hosts, and the resulting offspring exploit the hosts resources to complete their development [1]. Many parasitoids also introduce venom gland derived proteins or polydnaviruses into the host during infection. These factors act through a variety of mechanisms to manipulate host biology in order to increase the fitness of the developing parasitoid offspring [2-4]. Many hosts mount immune responses to parasitoid infection, and accordingly, parasitoids have evolved multiple venom genes that encode immunom ...

genomics

BugBase Predicts Organism Level Microbiome Phenotypes

Shotgun metagenomics and marker gene amplicon sequencing can be used to directly measure or predict the functional repertoire of the microbiota en masse, but current methods do not readily estimate the functional capability of individual microorganisms. Here we present BugBase, an algorithm that predicts organism-level coverage of functional pathways as well as biologically interpretable phenotypes such as oxygen tolerance, Gram staining and pathogenic potential, within complex microbiomes using either whole-genome shotgun or marker gene sequencing data. We find BugBases organism-level pathway coverage predictions to be statistically higher powered than current bag-of-genes approaches for discerning functional changes in both host-associated and environmental microbiomes.

bioinformatics