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Lapp, C. J.

Publications and source records attributed to Lapp, C. J..

2 recordsLinked to original sources

Selected for the surface: adaptive laboratory evolution for accelerated cathodic biofilm development in Cupriavidus necator

Cupriavidus necator is a metabolically versatile facultative chemolithoautotroph and a promising chassis for sustainable bioproduction from CO2. Efficient coupling of its metabolism to renewable electricity through microbial electrosynthesis (MES) requires the organism to form stable, electroactive biofilms on cathodes. This step is hindered under oxic conditions (oxic MES, oMES) by electrochemically generated reactive oxygen species (ROS), mass-transfer limitations and poor biofilm stability. Systematic strategies to improve C. necator biofilm formation on cathodes have been lacking. Here we used adaptive laboratory evolution (ALE) to address this gap. The progenitor strain colonised graphite cathodes only after an initial heterotrophic phase and formed spatially uneven biofilms whose distribution mirrored the local flow field, as resolved by micro-particle tracking velocimetry. Populations were then selected over five passages under controlled, oxygen-limited cathodic conditions. Resequencing revealed that the recovered population was genetically heterogeneous, and its dominant isolate, strain 890, was characterised in a microfluidic oMES platform. Strain 890 reached the target electrode coverage in about one day instead of six and maintained a robust biofilm at the progenitor's steady-state biovolume, whereas the multi-strain pool peaked higher but proved unstable. Relative to the progenitor, the accelerated biofilm phenotype of strain 890 is driven by a single novel mutation in a bifunctional diguanylate cyclase/phosphodiesterase locus, which likely encodes a central regulator of the planktonic-to-biofilm transition. The steady-state biovolume itself remained bounded, most probably due to a mass-transfer ceiling set by the counter-directional supply of H2 and O2. This work shows that ALE renders the initial-attachment barrier of cathodic biofilm formation genetically tractable, providing strain 890 as a robust chassis and a well-defined starting point for oMES-based CO2 valorisation.

bioengineering↗

Restriction-site-based enrichment coupled to adaptive sampling enables long-read transposon-insertion sequencing

Long-read Transposon insertion sequencing is essential for linking genotypes to phenotypes, as short-read approaches struggle with complex genomic regions. Long-read sequencing demands high sequencing depth or targeted sequencing, which either requires extensive sample preparation or suffer from low net efficiency. We developed a simple, low-cost workflow combining enzymatic cleavage with adaptive sampling to drastically improve target recovery and simplify analysis. I-SceI restriction site was introduced into a mini-Tn5 transposon to generate a mutant library in Cupriavidus necator. Prior to Nanopore sequencing, gDNA was digested to introduce double-strand breaks precisely at insertion sites, followed by sequencing with adaptive sampling. The workflow was validated via a biofilm selection screen. Combining I-SceI digestion with adaptive sampling yielded an effective 11.3-fold enrichment (after normalizing for pore occupancy). High-depth sequencing covered 97.1% of all genes. Because reads consistently began at the exact insertion site, bioinformatic trimming was bypassed. The biofilm screen successfully identified enriched integration loci, uniquely mapped insertions within repetitive rRNA operons, and revealed co-selected, spontaneous secondary mutations.This method adds less than one hour to library preparation, reduces consumable costs by over 90%, and establishes a budget-friendly, simple and high-resolution long-read Tn-seq pipeline ideal for complex and multipartite genomes. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=78 SRC="FIGDIR/small/733934v1_ufig1.gif" ALT="Figure 1"> View larger version (13K): org.highwire.dtl.DTLVardef@e1533aorg.highwire.dtl.DTLVardef@11f3ebborg.highwire.dtl.DTLVardef@4f94b3org.highwire.dtl.DTLVardef@ab7d29_HPS_FORMAT_FIGEXP M_FIG C_FIG

genomics↗