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Biology subjects

Landys, M.

Publications and source records attributed to Landys, M..

2 recordsLinked to original sources

Public exams provide opportunities for deeper thought with less anxiety

Assessment methods across post-secondary STEM education are traditionally constrained by logistics and likely contribute to the widespread inequities in STEM education outcomes. As part of attempts to improve and diversify the methods used in assessment, the authors have developed a flexible and low-tech style known as public exams based in educational best practices. Public exams attempt to authentically involve students into the process of assessment through the use of pre-released portions of the exam. Using mixed-methods research techniques at a closely matched pair of institutions (a research-intensive university and a community college classroom), we observed signals of positive impact from the public exam on student learning experiences. Public exams appear to promote deeper thought, to direct students more efficiently to the core concepts in the discipline, and to decrease student anxiety around exams. The public exam experience does not show evidence for exacerbating gaps in exam outcomes for students from underrepresented backgrounds. This suggests that public exams are worth deeper investigation as an evidence-based and effective assessment style.

scientific communication and education↗

SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

Controlling the global COVID-19 pandemic depends, among other measures, on developing preventive vaccines at an unprecedented pace. Vaccines approved for use and those in development intend to use neutralizing antibodies to block viral sites binding to the hosts cellular receptors. Virus infection is mediated by the spike glycoprotein trimer on the virion surface via its receptor binding domain (RBD). Antibody response to this domain is an important outcome of the immunization and correlates well with viral neutralization. Here we show that macromolecular constructs with recombinant RBD conjugated to tetanus toxoid induce a potent immune response in laboratory animals. Some advantages of the immunization with the viral antigen coupled to tetanus toxoid have become evident such as predominant IgG immune response due to affinity maturation and long-term specific B-memory cells. This paper demonstrates that subunit conjugate vaccines can be an alternative for COVID-19, paving the way for other viral conjugate vaccines based on the use of small viral proteins involved in the infection process.

immunology↗