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Lalanne, L.

Publications and source records attributed to Lalanne, L..

2 recordsLinked to original sources

Passage of time at the level of milliseconds: a new approach and a selective difficulty in individuals with schizophrenia

Background and HypothesisIndividuals with schizophrenia report that to them time sometimes feels discontinuous. Previous work has shown a link between the sense of self, and the ability to prepare to react to a target and to benefit from the passage of time, at the level of a few hundreds of milliseconds. However, the sense of time continuity requires a higher time resolution than examined in previous studies. Here we investigate to which extent individuals with schizophrenia and controls benefit from an increased delay when detecting asynchronies in the order of tens of milliseconds (stimulus onset asynchronies, i.e. SOA) between two successive visual stimuli. Study DesignWe re-analyzed three datasets and contrasted performance when the SOA increases, remains identical or decreases from trial t-1 to trial t. Study ResultsPerformance of all participants improved with an increase in the SOA, as the task became easier, but for controls more so than individuals with schizophrenia. These results are replicated across datasets, and were specific to the condition when SOA increased from one trial to the next. There was no significant group difference when the SOA decreased or remained identical. This was true even when the latter condition was more frequent, and when SOA magnitude was equalized across the conditions. Importantly, the difference between the two groups was specific to temporal judgements, and was not observed in a control masking task. ConclusionsWe suggest the results reveal a difficulty for individuals with schizophrenia to experience time at the level of milliseconds.

neuroscience↗

Sex-divergent brain epigenetic reprogramming by chronic opioids

Opioid use disorder (OUD) is a chronic condition that exhibits sex differences in prevalence, symptoms and treatment. Yet, the epigenetic mechanisms underlying these differences remain largely unknown. Here, we investigated the nucleus accumbens, a key brain region in OUD, to define the multiomic consequences of chronic morphine exposure in male and female mice. We profiled DNA methylation, five histone post-translational modifications, and their transcriptional effects at bulk and cell-type-specific levels. Despite comparable tissue organization and neurophysiological responses to morphine, epigenetic adaptations occurred at highly sex-specific genomic loci. These adaptations nevertheless followed common mechanistic principles, acting at similar gene features and transcription factor binding sites across sexes. Strikingly, they converged on overlapping genes, biological functions, and co-expression modules, and partially recapitulated transcriptional signatures of OUD in men and women. Therefore, our findings uncover a profound epigenetic sex divergence that mediates convergent biological dysregulation, and highlight opportunities for developing improved therapeutic strategies tailored to sex-specific mechanisms.

neuroscience↗